Algorithms for inferring haplotypes

T Niu - Genetic Epidemiology: The Official Publication of the …, 2004 - Wiley Online Library
Haplotype phase information in diploid organisms provides valuable information on human
evolutionary history and may lead to the development of more efficient strategies to identify …

A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis. bio-x. cn)

Z Li, Z Zhang, Z He, W Tang, T Li, Z Zeng, L He, Y Shi - Cell research, 2009 - nature.com
Haplotypic information in diploid organisms provides valuable information on human
evolutionary history and plays an important role in identifying a candidate gene in the …

A new statistical method for haplotype reconstruction from population data

M Stephens, NJ Smith, P Donnelly - The American Journal of Human …, 2001 - cell.com
Current routine genotyping methods typically do not provide haplotype information, which is
essential for many analyses of fine-scale molecular-genetics data. Haplotypes can be …

Haplotyping methods for pedigrees

G Gao, DB Allison, I Hoeschele - Human heredity, 2009 - karger.com
Haplotypes provide valuable information in the study of diseases, complex traits, population
histories, and evolutionary genetics. With the dramatic increase in the number of available …

Comparison of the accuracy of methods of computational haplotype inference using a large empirical dataset

RM Adkins - BMC genetics, 2004 - Springer
Background Analyses of genetic data at the level of haplotypes provide increased accuracy
and power to infer genotype-phenotype correlations and evolutionary history of a locus …

Comparisons of two methods for haplotype reconstruction and haplotype frequency estimation from population data

S Zhang, AJ Pakstis, KK Kidd, H Zhao - The American Journal of Human …, 2001 - cell.com
Haplotype reconstruction is an important issue, both in population genetics and in the
identification of complex disease genes. Stephens et al.(2001) proposed a new statistical …

Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data

D Fallin, NJ Schork - The American Journal of Human Genetics, 2000 - cell.com
Haplotype analyses have become increasingly common in genetic studies of human
disease because of their ability to identify unique chromosomal segments likely to harbor …

Partition-ligation–expectation-maximization algorithm for haplotype inference with single-nucleotide polymorphisms

ZS Qin, T Niu, JS Liu - The American Journal of Human Genetics, 2002 - cell.com
The mapping of SNPs in human genomes has generated a lot of interest from both the
biomedical research community and industry. In conjunction with SNP mapping, researchers …

Understanding the accuracy of statistical haplotype inference with sequence data of known phase

AM Andrés, AG Clark, L Shimmin… - … Official Publication of …, 2007 - Wiley Online Library
Statistical methods for haplotype inference from multi‐site genotypes of unrelated
individuals have important application in association studies and population genetics …

A comparison of bayesian methods for haplotype reconstruction from population genotype data

M Stephens, P Donnelly - The American Journal of Human Genetics, 2003 - cell.com
In this report, we compare and contrast three previously published Bayesian methods for
inferring haplotypes from genotype data in a population sample. We review the methods …