Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates
histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of …

Abstract Lysine (K)-specific demethylase 1A (LSD1/KDM1A) has been identified as a
potential therapeutic target in solid cancers and more recently in acute myeloid leukemia …

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful
model system to uncover fundamental mechanisms that control cellular identity during …

Epigenetic mechanisms underlie the phenotypic plasticity of cells, while aberrant epigenetic
regulation through genetic mutations and/or misregulated expression of epigenetic factors …

The development of the hematopoietic system is a dynamic process that is controlled by the
interplay between transcriptional and epigenetic networks to determine cellular identity …

The histone demethylase KDM6B (JMJD3) is upregulated in blood disorders, suggesting
that it may have important pathogenic functions. Here we examined the function of Kdm6b in …

Histone methylation is a dynamic and reversible process proposed to directly impact on
stem cell fate. The Jumonji (JmjC) domain–containing family of demethylases comprises 27 …

Abstract KDM4/JMJD2 are H3K9-and H3K36-specific demethylases, which are considered
promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring …

Throughout development, cell fate decisions are converted into epigenetic information that
determines cellular identity. Covalent histone modifications are heritable epigenetic marks …

Histone methylation plays a key role in the regulation of chromatin structure, and its
dynamics regulates important cellular processes. The investigation of the role of alterations …