Significant impact of time-of-day variation on metformin pharmacokinetics
Aims/hypothesis The objective was to investigate if metformin pharmacokinetics is
modulated by time-of-day in humans using empirical and mechanistic pharmacokinetic …
modulated by time-of-day in humans using empirical and mechanistic pharmacokinetic …
Pharmacokinetics and comparative bioavailability of two metformin formulations after single-dose administration in healthy subjects
I Atanasova, K Bozhinova, D Todorova… - Clinical drug …, 2003 - Springer
Objective: To assess the average bioequivalence of two formulations of metformin after
single-dose administration of each treatment to healthy subjects under fasting conditions by …
single-dose administration of each treatment to healthy subjects under fasting conditions by …
A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: an open-label, parallel group, randomized clinical study
Background The aim of this study was to explore the pharmacokinetic-pharmacodynamic
(PK-PD) relationship of metformin on glucose levels after the administration of 250 mg and …
(PK-PD) relationship of metformin on glucose levels after the administration of 250 mg and …
Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect
D Stepensky, M Friedman, I Raz, A Hoffman - Drug Metabolism and …, 2002 - ASPET
Metformin, a commonly used antidiabetic drug, exerts its glucose-lowering effect due to
metabolic activities at several sites of action (biophases), including liver, intestine, muscle …
metabolic activities at several sites of action (biophases), including liver, intestine, muscle …
Physiologically based pharmacokinetic modelling and prediction of metformin pharmacokinetics in renal/hepatic-impaired young adults and elderly populations
S Rhee, H Chung, SJ Yi, KS Yu, JY Chung - European journal of drug …, 2017 - Springer
Background and objectives Physiologically based pharmacokinetic (PBPK) modelling and
simulation enable researchers to overcome practical limitations for clinical trials on special …
simulation enable researchers to overcome practical limitations for clinical trials on special …
Using a limited sampling strategy to investigate the interindividual pharmacokinetic variability in metformin: A large prospective trial
I Kuhlmann, S Arnspang Pedersen… - British Journal of …, 2021 - Wiley Online Library
Aims Recently a limited sampling strategy (LSS) for determination of metformin'
pharmacokinetics was developed. The LSS utilizes the plasma concentration of metformin 3 …
pharmacokinetics was developed. The LSS utilizes the plasma concentration of metformin 3 …
Population pharmacokinetics of metformin in healthy subjects and patients with type 2 diabetes mellitus: simulation of doses according to renal function
Abstract Background and Objective Metformin is contraindicated in patients with renal
impairment; however, there is poor adherence to current dosing guidelines. In addition, the …
impairment; however, there is poor adherence to current dosing guidelines. In addition, the …
A pharmacometabolomic approach to predict response to metformin in early-phase type 2 diabetes mellitus patients
Metformin is a first-line medication for type 2 diabetes mellitus (T2DM). Based on its
universal use, the consideration of inter-individual variability and development of predictive …
universal use, the consideration of inter-individual variability and development of predictive …
Limited sampling strategy for determining metformin area under the plasma concentration–time curve
AB Santoro, TB Stage, CJ Struchiner… - British journal of …, 2016 - Wiley Online Library
Aim The aim was to develop and validate limited sampling strategy (LSS) models to predict
the area under the plasma concentration–time curve (AUC) for metformin. Methods …
the area under the plasma concentration–time curve (AUC) for metformin. Methods …
Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model
RA Posma, LH Venema, TM Huijink… - BMJ Open Diabetes …, 2020 - drc.bmj.com
Introduction Metformin can accumulate and cause lactic acidosis in patients with renal
insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by …
insufficiency. Metformin is known to inhibit mitochondria, while renal secretion of the drug by …