Aging-related cognitive decline is an emerging health crisis; however, no established
unifying mechanism has been identified for the cognitive impairments seen in an aging …

An increased pulse pressure, due to arteries stiffening with age and cardiovascular disease,
may lead to downstream brain damage in microvessels and cognitive decline. Brain-wide …

Background Non-invasive high-resolution imaging of the cerebral vascular anatomy and
function is key for the study of intracranial aneurysms, stenosis, arteriovenous …

The advent of neuroimaging has increased our understanding of brain function. While most
brain-wide functional imaging modalities exploit neurovascular coupling to map brain …

Age-related blood-brain barrier (BBB) disruption and cerebromicrovascular rarefaction
contribute importantly to the pathogenesis of both vascular cognitive impairment and …

Objective: Cerebrovascular disorders are associated with Alzheimer's disease (AD).
Functional analysis of the cerebral vasculature requires an in vivo approach to visualize the …

Abstract Changes in cerebral blood flow are associated with stroke, aneurysms, vascular
cognitive impairment, neurodegenerative diseases and other pathologies. Brain …

Background The vascular contributions to neurodegeneration and neuroinflammation may
be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review …

Rationale: Structure and function of the microvasculature provides critical information about
disease state, can be used to identify local regions of pathology, and has been shown to be …

In age-related neurodegenerative diseases, pathology often develops slowly across the
lifespan. As one example, in diseases such as Alzheimer's, vascular decline is believed to …