Rationale: Pulmonary sarcoidosis is classically defined by T-helper (Th) cell type 1
inflammation (eg, IFN-γ production by CD4+ effector T cells). Recently, IL-17A–secreting …

The lung-draining mediastinal lymph nodes (MLNs) are currently widely used to diagnose
sarcoidosis. We previously reported that T-helper (Th) 17.1 cells are responsible for the …

Background and aims Sarcoidosis is characterised by a compartmentalisation of CD4+ T
helper 1 (Th1) lymphocytes and activated macrophages in involved organs, including the …

Objective. Sarcoidosis is a systemic inflammatory disorder characterized by granulomas.
Although the aetiology is unknown, sarcoidosis is thought to be mediated by Th1 …

Disease phenotypes of pulmonary sarcoidosis are distinguished by clinical rather than
immunological criteria. We aimed to characterise patterns of CD4+ T-cell lineage plasticity …

Sarcoidosis is a systemic chronic granulomatous disease of unknown cause. Recent
investigations revealed that the cytokine profile in inflamed lesions of sarcoidosis is Th1 …

Background: Sarcoidosis is a systemic granulomatous disorder of unknown origin.
Lymphocytic inflammation is dominated by expression of Th1 type cytokines such as tumour …

BACKGROUND Pulmonary sarcoidosis is characterised by a mononuclear alveolitis with a
predominance of CD4+ T cells and macrophages. We determined the intracellular …

Cytokines released by T lymphocytes activated in the course of sarcoidosis, eg, interleukin-2
(IL-2) and interferon-gamma (IFN-gamma), indicate the presence of Th1 cells leading to the …

In pulmonary sarcoidosis, activated T cells accumulate in the lungs. We hypothesized that
the balance between the T-helper type 1 (Th1) cytokines (interferon [IFN]-γ and interleukin …