Newly identified structures of trace-amine associated receptor-1 (TAAR1) will aid discovery of next generation neuropsychiatric drugs
PC Nair, B Shajan, T Bastiampillai - Mol Psychiatry, 2024 - nature.com
The trace-amine associated receptor-1 (TAAR1) is a member of the G-protein coupled
receptor (GPCR) receptor family and is widely distributed across the brain and …
receptor (GPCR) receptor family and is widely distributed across the brain and …
Discovery of trace amine-associated receptor 1 ligands by molecular docking screening against a homology model
Trace Amines (TA) are side-products of the synthesis of classical neurotransmitters within
the brain. TAs exert their effect by binding to a family of G protein-coupled receptors termed …
the brain. TAs exert their effect by binding to a family of G protein-coupled receptors termed …
In-vivo pharmacology of trace-amine associated receptor 1
VM Lam, S Espinoza, AS Gerasimov… - European journal of …, 2015 - Elsevier
Trace-amines (TAs) are endogenous amines that are implicated in several physiological
processes including modulation of aminergic neurotransmission. These compounds exert …
processes including modulation of aminergic neurotransmission. These compounds exert …
Insights into the Structure and Pharmacology of the Human Trace Amine‐Associated Receptor 1 (hTAAR1): Homology Modelling and Docking Studies
E Cichero, S Espinoza, RR Gainetdinov… - Chemical biology & …, 2013 - Wiley Online Library
Trace amine‐associated receptor 1 (TAAR1) is a G protein–coupled receptor that belongs to
the family of TAAR receptors and responds to a class of compounds called trace amines …
the family of TAAR receptors and responds to a class of compounds called trace amines …
Ligand recognition and G-protein coupling of trace amine receptor TAAR1
Trace-amine-associated receptors (TAARs), a group of biogenic amine receptors, have
essential roles in neurological and metabolic homeostasis. They recognize diverse …
essential roles in neurological and metabolic homeostasis. They recognize diverse …
[HTML][HTML] Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges
The discovery in 2001 of a G protein-coupled receptor family, subsequently termed trace
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …
Trace Amine-Associated Receptor 1 (TAAR1): A new drug target for psychiatry?
S Dodd, AF Carvalho, BK Puri, M Maes… - Neuroscience & …, 2021 - Elsevier
There are nine subfamilies of TAARs. They are predominantly intracellular, located in the
central nervous system and peripherally. They have a role in homeostasis and rheostasis …
central nervous system and peripherally. They have a role in homeostasis and rheostasis …
[HTML][HTML] Non-functional trace amine-associated receptor 1 variants in patients with mental disorders
G Rutigliano, J Bräunig, C Del Grande… - Frontiers in …, 2019 - frontiersin.org
Background: The G protein–coupled receptor (GPCR) trace amine-associated receptor 1
(TAAR1) is expressed across brain areas involved in emotions, reward and cognition, and …
(TAAR1) is expressed across brain areas involved in emotions, reward and cognition, and …
[HTML][HTML] Therapeutic potential of TAAR1 agonists in schizophrenia: evidence from preclinical models and clinical studies
Trace amine-associated receptor 1 (TAAR1) has emerged as a promising therapeutic target
for neuropsychiatric disorders due to its ability to modulate monoaminergic and …
for neuropsychiatric disorders due to its ability to modulate monoaminergic and …
Structural and signaling mechanisms of TAAR1 enabled preferential agonist design
P Shang, N Rong, JJ Jiang, J Cheng, MH Zhang… - Cell, 2023 - cell.com
Trace amine-associated receptor 1 (TAAR1) senses a spectrum of endogenous amine-
containing metabolites (EAMs) to mediate diverse psychological functions and is useful for …
containing metabolites (EAMs) to mediate diverse psychological functions and is useful for …