BACKGROUND: Thyroid hormone signaling is critical for development, growth and
metabolic control in vertebrates. Although serum concentration of thyroid hormone is …

Thyroid hormone action can be customized on a cell-specific fashion through the controlled
action of the deiodinase group of enzymes, which are homodimeric thioredoxin fold …

Thyroid hormone signaling is customized in a time and cell-specific manner by the
deiodinases, homodimeric thioredoxin fold containing selenoproteins. This ensures …

The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …

The thyroid hormone plays a fundamental role in the development, growth, and metabolic
homeostasis in all vertebrates by affecting the expression of different sets of genes. A group …

The thyroid gland predominantly secretes the pro-hormone thyroxine (T4) that is converted
to the active hormone 3, 5, 30-L-triiodothyronine (T3) in target cells. Conversion of T4 to T3 …

The goal of this review is to place the exciting advances that have occurred in our
understanding of the molecular biology of the types 1, 2, and 3 (D1, D2, and D3 …

The major physiologic function of type 1 iodothyronine deiodinase (D1) is to produce
triiodothyronine (T3) for the plasma. D1 activity is regulated by numerous factors, perhaps …

Deiodinases modify the biological activity of thyroid hormone (TH) molecules, ie, they may
activate thyroxine (T4) to 3, 5, 3′-triiodothyronine (T3), or they may inactivate T3 to 3, 3 …

Thyroid hormone (TH) signaling is strictly regulated by iodothyronine deiodinase activity,
which both preserves the circulating levels of the biologically active triiodothyronine (T3) and …