Hypoxia has been shown to increase the aggressiveness and severity of tumor progression.
Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling …

The deleterious effects of intermittent hypoxia (IH) on cancer biology have been primarily
evaluated in the context of the aberrant circulation observed in solid tumors which results in …

A compelling body of evidence indicates that most human solid tumors contain hypoxic
areas. Hypoxia is the consequence not only of the chaotic proliferation of cancer cells that …

Obstructive sleep apnea (OSA) is common and linked to a variety of poor health outcomes. A
key modulator of this disease is nocturnal intermittent hypoxia. There is striking …

Simple Summary The term hypoxia is used to describe biological situations where
insufficient levels of oxygen exist. Hypoxia and hypoxic states can occur in a range of …

Obstructive sleep apnea (OSA) affects a significant proportion of the population and is linked
to increased rates of cancer development and a worse cancer outcome. OSA is …

Background Recently, increased tumor incidence and cancer-related mortality have been
reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the …

The purpose of this study was to evaluate whether obstructive sleep apnea (OSA)-related
chronic intermittent hypoxia (CIH) influences lung cancer progression and to elucidate the …

Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

There is an important and strong, but complex influence of the tumor microenvironment on
tumor cells׳ phenotype, aggressiveness, and treatment sensitivity. One of the most frequent …