An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells

MM Lamers, J van Der Vaart, K Knoops… - The EMBO …, 2021 - embopress.org
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus
disease 2019 (COVID‐19), which may result in acute respiratory distress syndrome (ARDS) …

A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant

MC Chiu, C Li, X Liu, Y Yu, J Huang, Z Wan, D Xiao… - Cell discovery, 2022 - nature.com
The airways and alveoli of the human respiratory tract are lined by two distinct types of
epithelium, which are the primary targets of respiratory viruses. We previously established …

Cell response analysis in SARS-CoV-2 infected bronchial organoids

E Sano, T Suzuki, R Hashimoto, Y Itoh… - Communications …, 2022 - nature.com
The development of an in vitro cell model that can be used to study severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) research is expected. Here we conducted infection …

[HTML][HTML] Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 …

CT Ekanger, F Zhou, D Bohan, ML Lotsberg… - Frontiers in cellular …, 2022 - frontiersin.org
The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of
unprecedented research efforts to understand the pathogenesis mediated by Severe Acute …

Human nasal organoids model SARS-CoV-2 upper respiratory infection and recapitulate the differential infectivity of emerging variants

MC Chiu, C Li, X Liu, W Song, Z Wan, Y Yu, J Huang… - MBio, 2022 - Am Soc Microbiol
The human upper respiratory tract, specifically the nasopharyngeal epithelium, is the entry
portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in …

Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection

R Pei, J Feng, Y Zhang, H Sun, L Li, X Yang, J He… - Protein & …, 2021 - academic.oup.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is caused by infection with
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is spread …

[PDF][PDF] Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2-mediated interferon responses and pneumocyte dysfunction

H Katsura, V Sontake, A Tata, Y Kobayashi… - Cell stem cell, 2020 - cell.com
Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …

[HTML][HTML] Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors

KM Abo, L Ma, T Matte, J Huang, KD Alysandratos… - Biorxiv, 2020 - ncbi.nlm.nih.gov
Abstract Development of an anti-SARS-CoV-2 therapeutic is hindered by the lack of
physiologically relevant model systems that can recapitulate host-viral interactions in human …

Advancing lung organoids for COVID-19 research

J van der Vaart, MM Lamers… - Disease Models & …, 2021 - journals.biologists.com
The COVID-19 pandemic has emphasised the need to develop effective treatments to
combat emerging viruses. Model systems that poorly represent a virus' cellular environment …

Generation of human bronchial organoids for SARS-CoV-2 research

T Suzuki, Y Itoh, Y Sakai, A Saito, D Okuzaki… - biorxiv, 2020 - biorxiv.org
Abstract Coronavirus disease 2019 (COVID-19) is a disease that causes fatal disorders
including severe pneumonia. To develop a therapeutic drug for COVID-19, a model that can …