An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus
disease 2019 (COVID‐19), which may result in acute respiratory distress syndrome (ARDS) …
disease 2019 (COVID‐19), which may result in acute respiratory distress syndrome (ARDS) …
A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant
The airways and alveoli of the human respiratory tract are lined by two distinct types of
epithelium, which are the primary targets of respiratory viruses. We previously established …
epithelium, which are the primary targets of respiratory viruses. We previously established …
Cell response analysis in SARS-CoV-2 infected bronchial organoids
E Sano, T Suzuki, R Hashimoto, Y Itoh… - Communications …, 2022 - nature.com
The development of an in vitro cell model that can be used to study severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) research is expected. Here we conducted infection …
syndrome coronavirus 2 (SARS-CoV-2) research is expected. Here we conducted infection …
[HTML][HTML] Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 …
CT Ekanger, F Zhou, D Bohan, ML Lotsberg… - Frontiers in cellular …, 2022 - frontiersin.org
The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of
unprecedented research efforts to understand the pathogenesis mediated by Severe Acute …
unprecedented research efforts to understand the pathogenesis mediated by Severe Acute …
Human nasal organoids model SARS-CoV-2 upper respiratory infection and recapitulate the differential infectivity of emerging variants
The human upper respiratory tract, specifically the nasopharyngeal epithelium, is the entry
portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in …
portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in …
Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection
R Pei, J Feng, Y Zhang, H Sun, L Li, X Yang, J He… - Protein & …, 2021 - academic.oup.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is caused by infection with
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is spread …
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is spread …
[PDF][PDF] Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2-mediated interferon responses and pneumocyte dysfunction
Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …
[HTML][HTML] Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors
Abstract Development of an anti-SARS-CoV-2 therapeutic is hindered by the lack of
physiologically relevant model systems that can recapitulate host-viral interactions in human …
physiologically relevant model systems that can recapitulate host-viral interactions in human …
Advancing lung organoids for COVID-19 research
J van der Vaart, MM Lamers… - Disease Models & …, 2021 - journals.biologists.com
The COVID-19 pandemic has emphasised the need to develop effective treatments to
combat emerging viruses. Model systems that poorly represent a virus' cellular environment …
combat emerging viruses. Model systems that poorly represent a virus' cellular environment …
Generation of human bronchial organoids for SARS-CoV-2 research
T Suzuki, Y Itoh, Y Sakai, A Saito, D Okuzaki… - biorxiv, 2020 - biorxiv.org
Abstract Coronavirus disease 2019 (COVID-19) is a disease that causes fatal disorders
including severe pneumonia. To develop a therapeutic drug for COVID-19, a model that can …
including severe pneumonia. To develop a therapeutic drug for COVID-19, a model that can …
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