There is an urgent need to identify modifiable environmental risk factors that reduce the
incidence of Alzheimer's disease (AD). The B‐like vitamin choline plays key roles in body …

Deficiency of dietary choline, an essential nutrient, is observed worldwide, with~ 90% of
Americans being deficient. Previous work highlights a relationship between decreased …

Background The positive association of choline for cognition has been reported in both
animal and human studies, yet the associations of choline with the risks of incident dementia …

The lack of effective treatments for Alzheimer's disease (AD) is alarming, considering the
number of people currently affected by this disorder and the projected increase over the next …

Currently, there are no effective therapies to ameliorate the pathological progression of
Alzheimer's disease (AD). Evidence suggests that environmental factors may contribute to …

Choline is an essential nutrient for humans. It is a precursor of membrane phospholipids (eg,
phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl …

Scope Alzheimer's disease (AD) is a detrimental neurodegenerative disease and has no
known effective treatment. The essential nutrient choline potentially plays an important role …

Choline is an essential nutrient that is required for normal development of the brain. Via its
metabolite betaine, it participates in the synthesis of S-adenosylmethionine, a major methyl …

Background and Aims: There is growing evidence suggesting choline intake might have
beneficial effects on cognitive function in the elderly. However, other studies reported no …

In order to determine brain and behavioral sensitivity of nutrients that may serve as inductive
signals during early development, we altered choline availability to rats during 7 time frames …