Conditional chemoconnectomics (cCCTomics) as a strategy for efficient and conditional targeting of chemical transmission
R Mao, J Yu, B Deng, X Dai, Y Du, S Du, W Zhang… - Elife, 2024 - elifesciences.org
Dissection of neural circuitry underlying behaviors is a central theme in neurobiology. We
have previously proposed the concept of chemoconnectome (CCT) to cover the entire …
have previously proposed the concept of chemoconnectome (CCT) to cover the entire …
[HTML][HTML] Conditional Chemoconnectomics (cCCTomics): Conditional Targeting of Chemical Transmission Efficiently
R Mao, J Yu, B Deng, X Dai, Y Du, S Du, W Zhang… - eLife, 2024 - elifesciences.org
Dissection of neural circuitry underlying behaviors is a central theme in neurobiology. We
have previously proposed the concept of chemoconnectome (CCT) to cover the entire …
have previously proposed the concept of chemoconnectome (CCT) to cover the entire …
[PDF][PDF] Chemoconnectomics: mapping chemical transmission in Drosophila
B Deng, Q Li, X Liu, Y Cao, B Li, Y Qian, R Xu, R Mao… - Neuron, 2019 - cell.com
We define the chemoconnectome (CCT) as the entire set of neurotransmitters,
neuromodulators, neuropeptides, and their receptors underlying chemotransmission in an …
neuromodulators, neuropeptides, and their receptors underlying chemotransmission in an …
Towards elucidating disease-relevant states of neurons and glia by CRISPR-based functional genomics
K Leng, M Kampmann - Genome Medicine, 2022 - Springer
Our understanding of neurological diseases has been tremendously enhanced over the past
decade by the application of new technologies. Genome-wide association studies have …
decade by the application of new technologies. Genome-wide association studies have …
Clock-enhancing small molecules and potential applications in chronic diseases and aging
GF Gloston, SH Yoo, Z Chen - Frontiers in neurology, 2017 - frontiersin.org
Normal physiological functions require a robust biological timer called the circadian clock.
When clocks are dysregulated, misaligned, or dampened, pathological consequences …
When clocks are dysregulated, misaligned, or dampened, pathological consequences …
Identification and development of clock-modulating small molecules–an emerging approach to fine-tune the disrupted circadian clocks
A Sultan - Biological rhythm research, 2019 - Taylor & Francis
Circadian timing system (CTS) enables living organisms to maintain circadian coherence in
physiology, metabolism, and behavior. Mammalian CTS comprises central clock; the …
physiology, metabolism, and behavior. Mammalian CTS comprises central clock; the …
[PDF][PDF] The excitatory, the inhibitory, and the modulatory: mapping chemical neurotransmission in the brain
T Boto, SM Tomchik - Neuron, 2019 - cell.com
The Excitatory, the Inhibitory, and the Modulatory: Mapping Chemical Neurotransmission in
the Brain Page 1 Neuron Previews The Excitatory, the Inhibitory, and the Modulatory …
the Brain Page 1 Neuron Previews The Excitatory, the Inhibitory, and the Modulatory …
[HTML][HTML] The Circadian Molecular Machinery in CNS Cells: A Fine Tuner of Neuronal and Glial Activity With Space/Time Resolution
F Fagiani, E Baronchelli, A Pittaluga… - Frontiers in Molecular …, 2022 - frontiersin.org
The circadian molecular machinery is a fine timekeeper with the capacity to harmonize
physiological and behavioral processes with the external environment. This tight-knit …
physiological and behavioral processes with the external environment. This tight-knit …
[HTML][HTML] Development of Circadian Clock Functions
The temporal organization of physiological functions such as sleep/wakefulness or body
temperature are regulated by the circadian clock. This intrinsic clock starts ticking in the …
temperature are regulated by the circadian clock. This intrinsic clock starts ticking in the …
Phase coupling of a circadian neuropeptide with rest/activity rhythms detected using a membrane-tethered spider toxin
Y Wu, G Cao, B Pavlicek, X Luo, MN Nitabach - PLoS biology, 2008 - journals.plos.org
Drosophila clock neurons are self-sustaining cellular oscillators that rely on negative
transcriptional feedback to keep circadian time. Proper regulation of organismal rhythms of …
transcriptional feedback to keep circadian time. Proper regulation of organismal rhythms of …