Summary Type 2 (non-insulin-dependent) diabetes mellitus is characterised by
hyperglycaemia, peripheral insulin resistance, impaired insulin secretion and pancreatic …

Islet amyloid polypeptide forms islet amyloid deposits in non-insulin-dependent diabetes
mellitus. We have generated transgenic mice which express human islet amyloid …

Abstract Islet amyloid polypeptide (“amylin”) is the major protein component of amyloid
deposits in pancreatic islets of type 2 (non‐insulin‐dependent) diabetic patients. Islet …

To determine whether chronic overproduction of islet amyloid polypeptide alters beta-cell
function, we studied a line of transgenic mice which overexpress islet amyloid polypeptide in …

To model islet amyloidogenesis in NIDDM and explore the glucoregulatory role of islet
amyloid polypeptide (IAPP), we have created transgenic micye containing a rat insulin‐I …

Pancreatic islet amyloid deposits are a characteristic pathologic feature of non-insulin-
dependent diabetes mellitus and contain islet amyloid polypeptide (IAPP; amylin). We used …

Islet amyloid derived from islet amyloid polypeptide (IAPP) is a well-recognized feature of
type II diabetes. However, the mechanism of islet amyloidogenesis is unknown. In vitro …

Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these deposits
contain the unique amyloidogenic peptide islet amyloid polypeptide. Autopsy studies in …

The islet in non-insulin-dependent diabetes mellitus (NIDDM) is characterized by loss of
beta cells and large local deposits of amyloid derived from the 37-amino acid protein, islet …

In this study, we determined the cDNA-predicted amino acid sequence of positions 9–31 of
islet amyloid polypeptide from the rabbit and European hare. A synthetic rabbit/hare islet …