Network for network concept offers new insights into host-SARS-CoV-2 protein interactions and potential novel targets for developing antiviral drugs

N Eskandarzade, A Ghorbani, S Samarfard… - Computers in biology …, 2022 - Elsevier
Abstract SARS-CoV-2, the causal agent of COVID-19, is primarily a pulmonary virus that can
directly or indirectly infect several organs. Despite many studies carried out during the …

A network biology approach to identify crucial host targets for COVID-19

RK Barman, A Mukhopadhyay, U Maulik, S Das - Methods, 2022 - Elsevier
The ongoing global pandemic of COVID-19, caused by SARS-CoV-2 has killed more than
5.9 million individuals out of∼ 43 million confirmed infections. At present, several parts of …

Analyzing host-viral interactome of sars-cov-2 for identifying vulnerable host proteins during covid-19 pathogenesis

JK Das, S Roy, PH Guzzi - Infection, Genetics and Evolution, 2021 - Elsevier
The development of therapeutic targets for COVID-19 relies on understanding the molecular
mechanism of pathogenesis. Identifying genes or proteins involved in the infection …

COVID-19: viral–host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection

F Messina, E Giombini, C Agrati, F Vairo… - Journal of translational …, 2020 - Springer
Background Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2
infection are under evaluation. A better understanding of the pathophysiology associated …

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Y Zhou, Y Liu, S Gupta, MI Paramo, Y Hou, C Mao… - Nature …, 2023 - nature.com
Studying viral–host protein–protein interactions can facilitate the discovery of therapies for
viral infection. We use high-throughput yeast two-hybrid experiments and mass spectrometry …

Looking for pathways related to COVID-19: confirmation of pathogenic mechanisms by SARS-CoV-2–host interactome

F Messina, E Giombini, C Montaldo, AA Sharma… - Cell Death & …, 2021 - nature.com
In the last months, many studies have clearly described several mechanisms of SARS-CoV-
2 infection at cell and tissue level, but the mechanisms of interaction between host and …

Pathway enrichment analysis of virus-host interactome and prioritization of novel compounds targeting the spike glycoprotein receptor binding domain–human …

P Gollapalli, S B. S, H Rimac, P Patil… - Journal of …, 2022 - Taylor & Francis
SARS-CoV-2 has become a pandemic causing a serious global health concern. The
absence of effective drugs for treatment of the disease has caused its rapid spread on a …

Interactome of SARS-CoV-2 modulated host proteins with computationally predicted PPIs: insights from translational systems biology studies

KB Karunakaran, N Balakrishnan… - Frontiers in Systems …, 2022 - frontiersin.org
Accelerated efforts to identify intervention strategies for the COVID-19 pandemic caused by
SARS-CoV-2 need to be supported by deeper investigations into host invasion and …

CovMulNet19, integrating proteins, diseases, drugs, and symptoms: a network medicine approach to COVID-19

N Verstraete, G Jurman, G Bertagnolli… - Network and systems …, 2020 - liebertpub.com
Introduction: We introduce in this study CovMulNet19, a comprehensive COVID-19 network
containing all available known interactions involving SARS-CoV-2 proteins, interacting …

[HTML][HTML] A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19

Y Zhou, Y Hou, J Shen, R Mehra, A Kallianpur… - PLoS …, 2020 - journals.plos.org
The global coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to unprecedented social and …