We discovered tolvaptan as a new Eg5 inhibitor using molecular dynamics simulation-based
virtual screening. The Eg5-monastrol, Eg5-ispinesib, and Eg5-STLC complexes with …

Although the structure has been elucidated for the binding of colchicine and podophyllotoxin
as potent destabilizer for microtubule formation, very little is known about MDL-27048, a …

Background: Mutant actins D157E and R183A-D184A are reported to resist the anticancer
drug Latrunculin A (LAT); though identified, the mechanism of resistance is not clearly …

The vasopressin V2 receptor (V2R) is a validated therapeutic target for autosomal dominant
polycystic kidney disease (ADPKD), with tolvaptan being the first FDA-approved antagonist …

Tolvaptan, a vasopressin receptor 2 antagonist used to treat hyponatremia, has recently
been reported to be associated with an increased risk of liver injury. In this study, we …

Microtubules play crucial role in process of mitosis and cell proliferation, which have been
considered as attractive drug targets for anticancer therapy. The aim of this study was to …

Microtubules play a critical role in mitosis and cell division and are regarded as an excellent
target for anticancer therapy. Although microtubule‐targeting agents have been widely used …

Microtubules (made up of α and β-tubulin subunits) play an essential role in the process of
mitosis and cell proliferation, thus making them an ideal target for anticancer drugs …

The in-silico strategy of identifying novel uses for already existing drugs, known as drug
repositioning, has enhanced drug discovery. Previous studies have shown a positive …

Microtubule cytoskeletons are involved in many essential functions throughout the life cycle
of cells, including transport of materials into cells, cell movement, and proper progression of …