Using Pulmonary Imaging to Move Chronic Obstructive Pulmonary Disease beyond FEV1

HO Coxson, J Leipsic, G Parraga… - American journal of …, 2014 - atsjournals.org
FEV1, measured using spirometry, provides a straightforward, widely available, and
inexpensive global measurement of airflow limitation and lung function. For decades, FEV1 …

FEV1/FEV6 to Diagnose Airflow Obstruction. Comparisons with Computed Tomography and Morbidity Indices

SP Bhatt, Y Kim, JM Wells, WC Bailey… - Annals of the …, 2014 - atsjournals.org
Rationale: FVC is a difficult maneuver for many patients, and forced expiratory volume in 6
seconds (FEV6) has been proposed as a surrogate for FVC for the diagnosis of chronic …

A Review of the Role of FEV1 in the COPD Paradigm

DE Doherty - COPD: Journal of Chronic Obstructive Pulmonary …, 2008 - Taylor & Francis
Historically, spirometry has been the objective measure used to confirm a symptom-based
clinical suspicion of COPD. The third National Health and Nutrition Examination Survey …

Chronic obstructive pulmonary disease: linking outcomes and pathobiology of disease modification

SI Rennard - Proceedings of the American Thoracic Society, 2006 - atsjournals.org
Recent guidelines define chronic obstructive pulmonary disease (COPD) as a preventable
and treatable disease characterized by airflow limitation and systemic consequences …

[HTML][HTML] Chronic obstructive pulmonary disease biomarker (s) for disease activity needed—urgently

J Vestbo, S Rennard - American Journal of Respiratory and Critical …, 2010 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation that is not fully reversible (1). Like many other major chronic diseases the burden …

[HTML][HTML] From GOLD 0 to pre-COPD

MLK Han, A Agusti, BR Celli, GJ Criner… - American journal of …, 2021 - atsjournals.org
The diagnosis of chronic obstructive pulmonary disease (COPD) currently requires the
demonstration of poorly reversible airflow limitation, defined as a post-bronchodilator …

Probing changes in lung physiology in COPD using CT, perfusion MRI, and hyperpolarized xenon-129 MRI

K Qing, NJ Tustison, JP Mugler III, JF Mata, Z Lin… - Academic radiology, 2019 - Elsevier
Rationale and Objectives Chronic obstructive pulmonary disease (COPD) is highly
heterogeneous and not well understood. Hyperpolarized xenon-129 (Xe129) magnetic …

Imaging advances in chronic obstructive pulmonary disease. Insights from the genetic epidemiology of chronic obstructive pulmonary disease (COPDGene) study

SP Bhatt, GR Washko, EA Hoffman… - American journal of …, 2019 - atsjournals.org
The Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study,
which began in 2007, is an ongoing multicenter observational cohort study of more than …

Pulmonary CT and MRI phenotypes that help explain chronic pulmonary obstruction disease pathophysiology and outcomes

EA Hoffman, DA Lynch, RG Barr… - Journal of Magnetic …, 2016 - Wiley Online Library
Pulmonary x‐ray computed tomographic (CT) and magnetic resonance imaging (MRI)
research and development has been motivated, in part, by the quest to subphenotype …

Risk factors for FEV1 decline in mild COPD and high-risk populations

S Chen, C Wang, B Li, G Shi, H Li, J Zhang… - … journal of chronic …, 2017 - Taylor & Francis
Background Early diagnosis of COPD is often not achieved due to limited recognition and
limited access to the pulmonary function test. Our hypothesis was that lung function decline …