Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
Background Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent
nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations …
nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations …
Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications
Nucleophosmin (NPM1) is a highly conserved nucleo-cytoplasmic shuttling protein that
shows a restricted nucleolar localization. Mutations of NPM1 gene leading to aberrant …
shows a restricted nucleolar localization. Mutations of NPM1 gene leading to aberrant …
The incidence and clinical significance of nucleophosmin mutations in childhood AML
P Brown, E McIntyre, R Rau… - Blood, The Journal …, 2007 - ashpublications.org
Frameshift mutations in exon 12 of the nucleophosmin gene (NPM1) result in aberrant
cytoplasmic localization of the NPM protein (NPMc+) and occur in 25% to 35% of adult acute …
cytoplasmic localization of the NPM protein (NPMc+) and occur in 25% to 35% of adult acute …
Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia
T Suzuki, H Kiyoi, K Ozeki, A Tomita, S Yamaji… - Blood, 2005 - ashpublications.org
Recently, somatic mutations of the nucleophosmin gene (NPM1), which alter the subcellular
localization of the product, have been reported in acute myeloid leukemia (AML). We …
localization of the product, have been reported in acute myeloid leukemia (AML). We …
Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features
B Falini, I Nicoletti, MF Martelli, C Mecucci - Blood, 2007 - ashpublications.org
The nucleophosmin (NPM1) gene encodes for a multifunctional nucleocytoplasmic shuttling
protein that is localized mainly in the nucleolus. NPM1 mutations occur in 50% to 60% of …
protein that is localized mainly in the nucleolus. NPM1 mutations occur in 50% to 60% of …
Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype
G Cazzaniga, MG Dell'Oro, C Mecucci, E Giarin… - Blood, 2005 - ashpublications.org
Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein involved in leukemia-
associated chromosomal translocations, and it regulates the alternate reading frame (ARF) …
associated chromosomal translocations, and it regulates the alternate reading frame (ARF) …
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved …
M Alcalay, E Tiacci, R Bergomas, B Bigerna… - Blood, 2005 - ashpublications.org
Approximately one third of acute myeloid leukemias (AMLs) are characterized by aberrant
cytoplasmic localization of nucleophosmin (NPMc+ AML), consequent to mutations in the …
cytoplasmic localization of nucleophosmin (NPMc+ AML), consequent to mutations in the …
Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin
We recently identified a new acute myeloid leukemia (AML) subtype characterized by
mutations at exon-12 of the nucleophosmin (NPM) gene and aberrant cytoplasmic …
mutations at exon-12 of the nucleophosmin (NPM) gene and aberrant cytoplasmic …
Nucleophosmin: a versatile molecule associated with hematological malignancies
T Naoe, T Suzuki, H Kiyoi, T Urano - Cancer science, 2006 - Wiley Online Library
Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome
assembly and transport, cytoplasmic–nuclear trafficking, centrosome duplication and …
assembly and transport, cytoplasmic–nuclear trafficking, centrosome duplication and …
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression …
RGW Verhaak, CS Goudswaard, W Van Putten, MA Bijl… - Blood, 2005 - ashpublications.org
Mutations in nucleophosmin NPM1 are the most frequent acquired molecular abnormalities
in acute myeloid leukemia (AML). We determined the NPM1 mutation status in a clinically …
in acute myeloid leukemia (AML). We determined the NPM1 mutation status in a clinically …