Background Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent
nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations …

Nucleophosmin (NPM1) is a highly conserved nucleo-cytoplasmic shuttling protein that
shows a restricted nucleolar localization. Mutations of NPM1 gene leading to aberrant …

Frameshift mutations in exon 12 of the nucleophosmin gene (NPM1) result in aberrant
cytoplasmic localization of the NPM protein (NPMc+) and occur in 25% to 35% of adult acute …

Recently, somatic mutations of the nucleophosmin gene (NPM1), which alter the subcellular
localization of the product, have been reported in acute myeloid leukemia (AML). We …

The nucleophosmin (NPM1) gene encodes for a multifunctional nucleocytoplasmic shuttling
protein that is localized mainly in the nucleolus. NPM1 mutations occur in 50% to 60% of …

Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein involved in leukemia-
associated chromosomal translocations, and it regulates the alternate reading frame (ARF) …

Approximately one third of acute myeloid leukemias (AMLs) are characterized by aberrant
cytoplasmic localization of nucleophosmin (NPMc+ AML), consequent to mutations in the …

We recently identified a new acute myeloid leukemia (AML) subtype characterized by
mutations at exon-12 of the nucleophosmin (NPM) gene and aberrant cytoplasmic …

Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome
assembly and transport, cytoplasmic–nuclear trafficking, centrosome duplication and …

Mutations in nucleophosmin NPM1 are the most frequent acquired molecular abnormalities
in acute myeloid leukemia (AML). We determined the NPM1 mutation status in a clinically …