G protein-coupled receptors (GPCRs) are the most common proteins targeted by approved
drugs. A complete mechanistic elucidation of large-scale conformational transitions …

Over one-third of current drugs target G-protein-coupled receptors (GPCRs). Leveraging the
phenomenon of biased signaling, where different ligands that bind to the same GPCR …

Functional selectivity of G protein–coupled receptor (GPCR) ligands toward different
downstream signals has recently emerged as a general hallmark of this receptor class …

G protein–coupled receptors engage both G proteins and β-arrestins, and their coupling can
be biased by ligands and mutations. Here, to resolve structural elements and mechanisms …

The angiotensin II (AngII) type 1 receptor (AT1R) is a critical regulator of cardiovascular and
renal function and is an important model for studies of G-protein-coupled receptor (GPCR) …

G protein-coupled receptors (GPCRs) shift between inactive non-signalling states and active
signalling states, to which intracellular binding partners can bind. Extracellular binding of …

G-protein-coupled receptors (GPCRs) are membrane proteins with critical functions in
cellular signal transduction, representing a primary class of drug targets. Acting by direct …

G-protein-coupled receptors (GPCRs) are membrane proteins that allosterically transduce
the signal of ligand binding in the extracellular (EC) domain to couple to proteins in the …

The angiotensin type 1 receptor (AT1R) and its octapeptide ligand, angiotensin II (AngII),
engage multiple downstream signaling pathways, including those mediated by …

The renin–angiotensin system (RAS) plays an important role in the pathophysiology of
cardiovascular disorders. Pharmacologic interventions targeting the RAS cascade have led …