Clinical exome sequencing routinely identifies missense variants in disease-related genes,
but functional characterization is rarely undertaken, leading to diagnostic uncertainty,. For …

The peroxisome proliferator-activated receptor-γ (PPARγ) is a transcription factor that has a
pivotal role in adipocyte differentiation and expression of adipocyte-specific genes 1, 3. The …

Genetic association studies are viewed as problematic and plagued by irreproducibility 1.
Many associations have been reported for type 2 diabetes 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 …

Peroxisome proliferator-activated receptor gamma (PPARG) is a master transcriptional
regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione …

Background There is increasing evidence of genetic factors leading to obesity, but the exact
genes involved have not been defined. Peroxisome-proliferator–activated receptor γ2 …

Peroxisome proliferator-activated receptor gamma (PPARγ), a ligand-regulated nuclear
hormone receptor, plays critical roles in metabolism and adipogenesis. PPARγ ligands such …

Peroxisome proliferator-activated receptor γ (PPARγ) is a transcription factor with a key role
in adipocyte differentiation. Since 1997, studies of rare mutations and common …

SNPs affecting disease risk often reside in non-coding genomic regions. Here, we show that
SNPs are highly enriched at mouse strain-selective adipose tissue binding sites for PPARγ …

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is a vital
regulator of adipogenesis, insulin sensitivity, and lipid metabolism. Activation of PPARγ by …

PPARγ is a member of the PPAR subfamily of nuclear receptors. In this work, the structure of
the human PPARγ cDNA and gene was determined, and its promoters and tissue-specific …