Drug repositioning is an approach that could accelerate the clinical use of compounds in
different diseases. The goal is to take advantage of the fact that approved drugs have been …

Phenothiazine derivatives possess biological properties very useful for cancer therapy, such
as antiemetic and sedative activity as well as good blood–brain barrier permeability. Our …

Drug repurposing is a strategy that can speed up and find novel clinical uses for already-
approved drugs for several diseases, such as cancer. This process is accelerated compared …

Phenothiazines belong to the oldest, synthetic antipsychotic drugs, which do not have their
precursor in the world of natural compounds. Apart from their fundamental neuroleptic action …

Phenothiazines, a kind of sulfur-containing tricyclic compounds, have diverse biological
activities including tranquilizer, antibacterial, antitumor and antihelmintic activities due to the …

Phenothiazines have been used in many areas of medicine, mainly in psychopharmacology.
These compounds are able to effectively inhibit dopamine, histamine, serotonin …

Heterocycles are common in the structure of drugs used clinically to deal with diseases.
Such drugs usually contain nitrogen, oxygen and sulfur, which possess electron-accepting …

Drug repositioning explores the reuse of non-cancer drugs to treat tumors. In this work, we
evaluated the effect of the combination of chloroquine and propranolol on colorectal and …

Objectives: To synthesize novel compounds belonging to Benzodioxane, Naphthalene
diimide, Aminophenol derivatives and Porphyrin classes and test their potential anticancer …

Penfluridol has robust antipsychotic efficacy and is a first-generation diphenylbutylpiperidine
. Its effects last for several days after a single oral dose and it can be administered once a …