Going beyond risk factor: childhood maltreatment and associated modifiable targets to improve life-long outcomes in mood disorders

ETC Lippard, CB Nemeroff - Pharmacology Biochemistry and Behavior, 2022 - Elsevier
Childhood maltreatment increases risk for mood disorders and is associated with earlier
onset—and more pernicious disease course following onset—of mood disorders. While the …

The devastating clinical consequences of child abuse and neglect: increased disease vulnerability and poor treatment response in mood disorders

ETC Lippard, CB Nemeroff - American journal of psychiatry, 2023 - psychiatryonline.org
A large body of evidence has demonstrated that exposure to childhood maltreatment at any
stage of development can have long-lasting consequences. It is associated with a marked …

[HTML][HTML] Analyzing pathways from childhood maltreatment to internalizing symptoms and disorders in children and adolescents (AMIS): a study protocol

LO White, AM Klein, C Kirschbaum, M Kurz-Adam… - BMC psychiatry, 2015 - Springer
Background Effective interventions for maltreated children are impeded by gaps in our
knowledge of the etiopathogenic mechanisms leading from maltreatment to mental …

Co-occurring childhood maltreatment exposure and depressive symptoms in adulthood: Testing differential effects of stress dysregulation and perceived stress

AA Mishra, K Marceau - Aging & Mental Health, 2020 - Taylor & Francis
Objectives: Objectives were to explore: 1) the association between sub-groups with different
multi-type childhood maltreatment exposures and depressive symptoms in late adulthood …

Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk …

CE Shenk, AM Griffin, KJ O'Donnell - Development and …, 2015 - cambridge.org
Major depressive disorder (MDD) is a prevalent psychiatric condition in the child
maltreatment population. However, not all children who have been maltreated will develop …

The impact of childhood maltreatment on biological systems: Implications for clinical interventions

A Gonzalez - Paediatrics & child health, 2013 - academic.oup.com
Childhood maltreatment represents a significant risk factor for the development of a number
of mental and physical health outcomes. Converging evidence suggests that early adversity …

Mood disorders in children and adolescents: an epidemiologic perspective

RC Kessler, S Avenevoli, KR Merikangas - Biological psychiatry, 2001 - Elsevier
Epidemiologic studies show that major depression is comparatively rare among children, but
common among adolescents, with up to a 25% lifetime prevalence by the end of …

[HTML][HTML] Paradise lost: the neurobiological and clinical consequences of child abuse and neglect

CB Nemeroff - Neuron, 2016 - cell.com
In the past two decades, much evidence has accumulated unequivocally demonstrating that
child abuse and neglect is associated with a marked increase in risk for major psychiatric …

Child maltreatment and the development of psychopathology: The role of developmental timing and chronicity

J Russotti, JM Warmingham, EB Duprey… - Child abuse & …, 2021 - Elsevier
Background The effects of child maltreatment (CM) on psychopathology are well-
established, yet the complex effects of timing and chronicity of maltreatment exposure on the …

Differential associations of childhood abuse and neglect with adult autonomic regulation and mood-related pathology

SK Stevens, DWP Williams, JF Thayer… - Psychosomatic …, 2023 - journals.lww.com
Objective This study assessed whether different types of childhood maltreatment (ie, abuse
versus neglect) had differential relationships with heart rate variability (HRV) and baroreflex …