For many tumor types concurrent chemoradiation is the standard of care for locally
advanced disease. Despite this intense treatment overall survival is still poor in various solid …

Non-small cell lung cancer (NSCLC) is a malignant lung tumor with a dismal prognosis. The
activation of the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway is common in …

Abstract The phosphatidylinositol-3-kinase (PI3-K)/protein kinase B (AKT) pathway is
associated with all three major radiation resistance mechanisms: intrinsic radiosensitivity …

Cell signaling initiated at the epidermal growth factor receptor (EGFR), RAS oncoproteins, or
PI3K contributes to a common pathway that promotes tumor survival after radiation-induced …

Radiotherapy is routinely used as a neoadjuvant, adjuvant or palliative treatment in various
cancers. There is significant variation in clinical response to radiotherapy with or without …

Activation of the phosphatidylinositol-3-kinase (PI3-K)/protein kinase B (AKT) pathway is
associated with three major radioresistance mechanisms: intrinsic radioresistance; tumour …

PURPOSE: Multiple genetic alterations such as in Ras or EGFR can result in sustained
signaling through PI3K. Our previous experiments have shown that resistance to radiation …

In recent years, cancer therapeutics development has emphasized the identification and
evaluation of 'targeted'drugs directed at specific molecular aspects in signaling pathways of …

There are ample genetic and laboratory studies that suggest the PI3K–Akt pathway is vital to
the growth and survival of cancer cells. Inhibitors targeting this pathway are entering the …

Results Western blot analysis showed that Akt was rapidly phosphorylated in response to
radiation in primary culture endothelial cells (HUVEC) in the absence of serum or growth …