A recap of RNA recapping

JB Trotman, DR Schoenberg - Wiley Interdisciplinary Reviews …, 2019 - Wiley Online Library
The N7‐methylguanosine cap is a hallmark of the 5′ end of eukaryotic mRNAs and is
required for gene expression. Loss of the cap was believed to lead irreversibly to decay …

RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs

JB Trotman, AJ Giltmier, C Mukherjee… - Nucleic acids …, 2017 - academic.oup.com
Cap homeostasis is a cyclical process of decapping and recapping that impacts a portion of
the mRNA transcriptome. The metastable uncapped forms of recapping targets redistribute …

Recent insights into noncanonical 5′ capping and decapping of RNA

SK Doamekpor, S Sharma, M Kiledjian… - Journal of Biological …, 2022 - ASBMB
The 5′ N 7-methylguanosine cap is a critical modification for mRNAs and many other RNAs
in eukaryotic cells. Recent studies have uncovered an RNA 5′ capping quality surveillance …

Structural and functional insights into eukaryotic mRNA decapping

SHM Ling, R Qamra, H Song - Wiley Interdisciplinary Reviews …, 2011 - Wiley Online Library
The control of messenger RNA (mRNA) translation and degradation is important in
regulation of eukaryotic gene expression. In the general and specialized mRNA decay …

The messenger RNA decapping and recapping pathway in Trypanosoma

AV Ignatochkina, Y Takagi, Y Liu… - Proceedings of the …, 2015 - National Acad Sciences
The 5′ terminus of trypanosome mRNA is protected by a hypermethylated cap 4 derived
from spliced leader (SL) RNA. Trypanosoma brucei nuclear capping enzyme with cap …

[HTML][HTML] Identification of cytoplasmic capping targets reveals a role for cap homeostasis in translation and mRNA stability

C Mukherjee, DP Patil, BA Kennedy, B Bakthavachalu… - Cell reports, 2012 - cell.com
The notion that decapping leads irreversibly to messenger RNA (mRNA) decay was
contradicted by the identification of capped transcripts missing portions of their 5′ ends and …

mRNA capping: biological functions and applications

A Ramanathan, GB Robb, SH Chan - Nucleic acids research, 2016 - academic.oup.com
The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades
of research have established that the m7G cap serves as a unique molecular module that …

To cap it all off, again: dynamic capping and recapping of coding and non-coding RNAs to control transcript fate and biological activity

KLB Borden, B Culjkovic-Kraljacic, VH Cowling - Cell Cycle, 2021 - Taylor & Francis
The addition of the methyl-7-guanosine (m7G)“cap” on the 5'ends of coding and some non-
coding RNAs is essential for their protein coding capacity and biochemical activity …

Ceg1 depletion reveals mechanisms governing degradation of non-capped RNAs in Saccharomyces cerevisiae

O Zanin, M Eastham, K Winczura, M Ashe… - Communications …, 2023 - nature.com
Most functional eukaryotic mRNAs contain a 5′ 7-methylguanosine (m7G) cap. Although
capping is essential for many biological processes including mRNA processing, export and …

Noncanonical RNA‐capping: Discovery, mechanism, and physiological role debate

C Julius, Y Yuzenkova - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
Recently a new type of 5′‐RNA cap was discovered. In contrast to the specialized
eukaryotic m7G cap, the novel caps are abundant cellular cofactors like NAD+. RNAs …