The intersection of capsule gene expression, hypermucoviscosity and hypervirulence in Klebsiella pneumoniae

KA Walker, VL Miller - Current opinion in microbiology, 2020 - Elsevier
For∼ 30 years, two distinct groups of clinical isolates of Klebsiella pneumoniae have been
recognized. Classical strains (cKp) are typically isolated from patients with some degree of …

The contribution of capsule polysaccharide genes to virulence of Klebsiella pneumoniae

KS Ko - Virulence, 2017 - Taylor & Francis
Klebsiella pneumoniae is a Gram-negative, non-motile bacterium that is found in the
environment, including in soil and surface water. K. pneumoniae readily colonizes human …

Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains

M Palacios, TA Miner, DR Frederick, VE Sepulveda… - MBio, 2018 - Am Soc Microbiol
Klebsiella pneumoniae is widely recognized as a pathogen with a propensity for acquiring
antibiotic resistance. It is capable of causing a range of hospital-acquired infections (urinary …

A Klebsiella pneumoniae regulatory mutant has reduced capsule expression but retains hypermucoviscosity

KA Walker, TA Miner, M Palacios, D Trzilova… - MBio, 2019 - Am Soc Microbiol
The polysaccharide capsule is an essential virulence factor for Klebsiella pneumoniae in
both community-acquired hypervirulent strains as well as health care-associated classical …

Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniaeinfections: comparative virulence analysis with hypermucoviscosity …

YC Lin, MC Lu, HL Tang, HC Liu, CH Chen, KS Liu… - BMC microbiology, 2011 - Springer
Background Klebsiella pneumoniae displaying the hypermucoviscosity (HV) phenotype are
considered more virulent than HV-negative strains. Nevertheless, the emergence of tissue …

Cell envelope defects of different capsule‐null mutants in K1 hypervirulent Klebsiella pneumoniae can affect bacterial pathogenesis

YH Tan, Y Chen, WHW Chu, LT Sham… - Molecular …, 2020 - Wiley Online Library
Hypervirulent Klebsiella pneumoniae (hvKP) causes Klebsiella‐induced liver abscess.
Capsule is important for the pathogenesis of Klebsiella in systemic infection, but its role in …

Genetic exchange of determinants for capsular polysaccharide biosynthesis between Klebsiella pneumoniae strains expressing serotypes K2 and K21a

I Ofek, K Kabha, A Athamna, G Frankel… - Infection and …, 1993 - Am Soc Microbiol
The production of a capsular polysaccharide (CPS; K antigen) is characteristic of Klebsiella
pneumoniae, but CPS structure varies among strains, and many different serotypes are now …

Capsular Types of Klebsiella pneumoniae Revisited by wzc Sequencing

YJ Pan, TL Lin, YH Chen, CR Hsu, PF Hsieh, MC Wu… - PloS one, 2013 - journals.plos.org
Capsule is an important virulence factor in bacteria. A total of 78 capsular types have been
identified in Klebsiella pneumoniae. However, there are limitations in current typing …

Hypervirulent Klebsiella pneumoniae: the Next Superbug?

AS Shon, TA Russo - Future microbiology, 2012 - Taylor & Francis
Future Microbiol.(2012) 7 (6) 670 future science group compromise (eg, neutropenia). Our
laboratory began studying hvKP after a case of CA-PLA with metastatic spread to the spleen …

Role of capsule in Klebsiella pneumoniae virulence: lack of correlation between in vitro and in vivo studies

C Struve, KA Krogfelt - FEMS microbiology letters, 2003 - academic.oup.com
In vitro and in vivo models were used to investigate the role of capsule on the virulence of
Klebsiella pneumoniae. We showed that capsule expression reduces dramatically the ability …