Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease

W Liang, Y Yang, S Gong, M Wei, Y Ma, R Feng… - Cell host & …, 2023 - cell.com
Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease
(COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression …

Inflammation and repair processes in chronic obstructive pulmonary disease

SI Rennard - American journal of respiratory and critical care …, 1999 - atsjournals.org
AM J RESPIR CRIT CARE MED 1999; 160: S12− S16. COPD is characterized by chronic
inflammation and injury of both the airways and the parenchymal structures of the lung …

Airway epithelial stem cells and the pathophysiology of chronic obstructive pulmonary disease

SH Randell - Proceedings of the American Thoracic Society, 2006 - atsjournals.org
Characteristic pathologic changes in chronic obstructive pulmonary disease (COPD) include
an increased fractional volume of bronchiolar epithelial cells, fibrous thickening of the airway …

[PDF][PDF] Oxidative stress in chronic obstructive pulmonary disease: a lung and systemic process

SF Van Eeden, DD Sin - Canadian Respiratory Journal, 2013 - Wiley Online Library
There is overwhelming evidence that oxidative stress and oxidative damage play a pivotal
role in the pathogenesis of chronic obstructive pulmonary disease (COPD)(1-3). The …

Systemic manifestations of COPD

Y Nussbaumer-Ochsner, KF Rabe - Chest, 2011 - Elsevier
COPD is characterized by a poorly reversible airflow limitation resulting from chronic
inflammation, mainly due to tobacco exposure. Over the past few years, the understanding of …

Chronic obstructive pulmonary disease biomarkers and their interpretation

RA Stockley, DMG Halpin, BR Celli… - American journal of …, 2019 - atsjournals.org
The pathology and impact of chronic obstructive pulmonary disease (COPD) results from an
abnormal inflammatory process resulting in tissue damage with ineffective repair in …

The pathogenesis of COPD and IPF: distinct horns of the same devil?

M Chilosi, V Poletti, A Rossi - Respiratory research, 2012 - Springer
New paradigms have been recently proposed in the pathogenesis of both chronic
obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), evidencing …