Method for high‐resolution imaging of creatine in vivo using chemical exchange saturation transfer
Purpose To develop a chemical exchange saturation transfer (CEST)‐based technique to
measure free creatine (Cr) and to validate the technique by measuring the distribution of Cr …
measure free creatine (Cr) and to validate the technique by measuring the distribution of Cr …
In vivo chemical exchange saturation transfer imaging of creatine (CrCEST) in skeletal muscle at 3T
Purpose To characterize the chemical exchange saturation transfer (CEST)‐based
technique to measure free creatine (Cr), a key component of muscle energy metabolism …
technique to measure free creatine (Cr), a key component of muscle energy metabolism …
Relaxation‐compensated CEST‐MRI at 7 T for mapping of creatine content and pH – preliminary application in human muscle tissue in vivo
The small biomolecule creatine is involved in energy metabolism. Mapping of the total
creatine (mostly PCr and Cr) in vivo has been done with chemical shift imaging. Chemical …
creatine (mostly PCr and Cr) in vivo has been done with chemical shift imaging. Chemical …
Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI
Creatine (Cr), phosphocreatine (PCr) and adenosine‐5‐triphosphate (ATP) are major
metabolites of the enzyme creatine kinase (CK). The exchange rate of amine protons of CK …
metabolites of the enzyme creatine kinase (CK). The exchange rate of amine protons of CK …
Chemical exchange saturation transfer imaging of phosphocreatine in the muscle
Purpose To determine the exchange parameters for the CEST of phosphocreatine
(PCrCEST) in phantoms and to characterize PCrCEST in vivo in the muscle at different …
(PCrCEST) in phantoms and to characterize PCrCEST in vivo in the muscle at different …
Creatine and phosphocreatine mapping of mouse skeletal muscle by a polynomial and Lorentzian line‐shape fitting CEST method
Purpose To obtain high‐resolution Cr and PCr maps of mouse skeletal muscle using a
polynomial and Lorentzian line‐shape fitting (PLOF) CEST method. Methods Wild‐type mice …
polynomial and Lorentzian line‐shape fitting (PLOF) CEST method. Methods Wild‐type mice …
Chemical exchange saturation transfer imaging of creatine, phosphocreatine, and protein arginine residue in tissues
Chemical exchange saturation transfer (CEST) MRI has become a promising technique to
assay target proteins and metabolites through their exchangeable protons, noninvasively …
assay target proteins and metabolites through their exchangeable protons, noninvasively …
Characterization of creatine guanidinium proton exchange by water‐exchange (WEX) spectroscopy for absolute‐pH CEST imaging in vitro
Chemical exchange saturation transfer (CEST) enables indirect detection of small
metabolites in tissue by MR imaging. To optimize and interpret creatine‐CEST imaging we …
metabolites in tissue by MR imaging. To optimize and interpret creatine‐CEST imaging we …
In vivo imaging of phosphocreatine with artificial neural networks
Phosphocreatine (PCr) plays a vital role in neuron and myocyte energy homeostasis.
Currently, there are no routine diagnostic tests to noninvasively map PCr distribution with …
Currently, there are no routine diagnostic tests to noninvasively map PCr distribution with …
Creatine supplementation--part II: in vivo magnetic resonance spectroscopy.
R Kreis, M Kamber, M Koster, J Felblinger… - Medicine and science …, 1999 - europepmc.org
Purpose Our purpose was to study effects of creatine (Cr) supplementation on muscle
metabolites noninvasively by means of magnetic resonance spectroscopy (MRS) before and …
metabolites noninvasively by means of magnetic resonance spectroscopy (MRS) before and …