To uncover the mechanism by which human prostate cancer progresses, we performed a
genetic screen for regulators of human prostate cancer progression using the Drosophila …

Prostate cancer is the most common cancer in aging men. Despite recent progress, there
are still few effective treatments to cure its aggressive and metastatic stages. A better …

Studies centered at the intersection of embryogenesis and carcinogenesis have identified
striking parallels involving signaling pathways that modulate both developmental and …

Although the basic functions of the prostate gland are conserved among mammals, its
morphology varies greatly among species. Comparative studies between mouse and human …

The human prostate is a gland of the male reproductive tract, which together with the
seminal vesicles, is responsible for most seminal fluid production. It is a common site of …

Mice have been used extensively for studying normal prostate development and for
generation of transgenic or knock-out prostate cancer animal models. To understand …

Abstract BACKGROUND Protocadherin‐PC (PCDH‐PC) expression is upregulated in
apoptosis‐resistant sublines of the LNCaP human prostate cancer (CaP) cell line. Here, we …

Abstract Protocadherin-PC (PCDH-PC) is a gene on the human Y chromosome that is
selectively expressed in apoptosis-and hormone-resistant human prostate cancer cells. The …

The molecular mechanisms that control prostate development have been intensely studied
in recent years due to the emergence of prostatic cancer as a major health concern. Several …

In Drosophila, over 50 genes have been identified in which loss-of-function mutations lead
to excess cell proliferation in the embryo, in the central nervous system, imaginai discs or …