Purpose STING-associated vasculopathy with onset in infancy (SAVI) is a type-I
interferonopathy, characterized by systemic inflammation, peripheral vascular inflammation …

STING-associated vasculopathy with onset in infancy (SAVI) is a type 1 interferonopathy that
is typically characterized by early onset systemic inflammation with cutaneous vasculitis and …

Background Gain-of-function mutations in STING1 underlie a type I interferonopathy termed
SAVI (STING-associated vasculopathy with onset in infancy). This severe disease is variably …

STING-associated vasculopathy with onset in infancy (SAVI) is a rare type Ι interferonopathy
caused by gain of function mutations in an encoding stimulator of interferon genes (STING) …

Stimulator of interferon genes (STING1) is a key intermediary in activating the type I IFN
response. STING-associated vasculopathy with onset in infancy (SAVI) is a very rare …

Gain-of-function variants in the stimulator of interferon response cGAMP interactor 1
(STING1) gene cause STING-Associated Vasculopathy with onset in Infancy (SAVI) …

STING-associated vasculopathy with onset in infancy (SAVI) is a rare form of inborn error of
immunity (IEI), belonging to the group of type I interferonopathies that usually affects children …

Stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI)
is a rare disorder that is associated with extensive inflammation throughout the body due to …

Type I interferons (IFNs) play a critical role in the innate immune response to pathogens, and
abnormal activation of IFN signaling underlies a group of autoinflammatory diseases …

Background Mutations in the gene encoding stimulator of interferon genes (STING) underlie
a type I interferon (IFN) associated disease, STING-associated vasculopathy with onset in …