Neurological disorders are the second cause of death and the leading cause of disability
worldwide. Unfortunately, no cure exists for these disorders, but the actual therapies are only …

At the level of in vitro drug screening, the development of a phenotypic analysis system with
high-content screening at the core provides a strong platform to support high-throughput …

Highlights•A lot of outstanding pioneering studies greatly boost the brain organoid
field.•Brain organoids are versatile models to study human neurodevelopment, neurological …

Simple Summary This review article describes an overview of the developed advanced
neural in vitro systems and the discovery of brain organoids including the recently …

Neurological disorders are challenging to study given the complexity and species-specific
features of the organ system. Brain organoids are three dimensional structured aggregates …

Clinical trials serve as the fundamental prerequisite for clinical therapy of human disease,
which is primarily based on biomedical studies in animal models. Undoubtedly, animal …

There is an urgent need for predictive in vitro models to improve disease modeling and drug
target identification and validation, especially for neurological disorders. Cerebral …

Brain organoids are self‐organized, three‐dimensional (3D) aggregates derived from
pluripotent stem cells that have cell types and cellular architectures resembling those of the …

The basic technology of stem cells has been developed and created organoids, which have
established a strong interest in regenerative medicine. Different cell types have been used …

The high failure rate of drugs in the clinical pipeline is likely in part the result of inadequate
preclinical models, particularly those for neurologic disorders and neurodegenerative …