Harnessing the potential of human embryonic stem cells to mimic normal and aberrant
development with standardized models is a pressing challenge. Here we use micropattern …

Neural cultures derived from Huntington's disease (HD) patient-derived induced pluripotent
stem cells were used for'omics' analyses to identify mechanisms underlying …

Increasing evidence suggests that early neurodevelopmental defects in Huntington's
disease (HD) patients could contribute to the later adult neurodegenerative phenotype …

Human telencephalon is an evolutionarily advanced brain structure associated with many
uniquely human behaviors and disorders. However, cell lineages and molecular pathways …

Cerebral organoids exhibit broad regional heterogeneity accompanied by limited cortical
cellular diversity despite the tremendous upsurge in derivation methods, suggesting …

Huntington's disease (HD) causes severe motor dysfunction, behavioral abnormalities,
cognitive impairment and death. Investigations into its molecular pathology have primarily …

Huntington's disease (HD) is a neurodegenerative disease caused by an expanded CAG
repeat in the Huntingtin (HTT) gene. Induced pluripotent stem cell (iPSC) models of HD …

Cells of a developing embryo integrate a complex array of local and long‐range signals that
act in concert with cell‐intrinsic determinants to influence developmental decisions. To …

The human nervous system is a highly complex but organized organ. The foundation of its
complexity and organization is laid down during regional patterning of the neural tube, the …

Most neurodegenerative diseases are linked to aberrant accumulation of aggregation‐prone
proteins. Among them, Huntington's disease (HD) is caused by an expanded polyglutamine …