Prenatal and postnatal co-exposure to multiple chemicals at the same time may have
deleterious effects on the developing nervous system. We previously showed that chemicals …

Background In light of the vulnerability of the developing brain, mixture risk assessment
(MRA) for the evaluation of developmental neurotoxicity (DNT) should be implemented …

Halogenated persistent organic pollutants (POPs) like perfluorinated alkylated substances
(PFASs), brominated flame retardants (BFRs), organochlorine pesticides and …

Currently, the identification of chemicals that have the potential to induce developmental
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …

Human induced pluripotent stem cell (hiPSC)-derived neural stem cells (NSCs) and their
differentiated neuronal/glial derivatives have been recently considered suitable to assess in …

A major challenge in regulatory developmental neurotoxicity (DNT) assessment is lack of
toxicological information for many compounds. Therefore, the Test Guidelines programme of …

Classical cases of developmental neurotoxicity (DNT) in humans and advances in risk
assessment methods did not prevent the emergence of new chemicals with (suspected) …

Newly synthesized chemicals are being introduced into the environment without undergoing
proper toxicological evaluation, particularly in terms of their effects on the vulnerable …

The goal of this systematic review performed under a contract with EFSA was the evaluation
of information on assessment methods in the field of developmental neurotoxicity (DNT) …

Simple Summary It is recognized that the current developmental neurotoxicity (DNT) testing
paradigm is not fit-for-purpose for the assessment of a large number of chemicals. In the last …