Lines of evidence coming from many branches of neuroscience indicate that anxiety
disorders arise from a dysfunction in the modulation of brain circuits which regulate …

Mechanisms underlying the pathological characteristics of the various anxiety disorders
have yet to be fully elucidated. One of the most widely accepted mediators known to play a …

Anxiety stems from and perpetuates dysregulation of neurobiological systems, but the exact
mechanisms of anxiety disorders are still only partially understood. Gamma-aminobutyric …

In the regulation of behavior, the role of GABA neurons has been extensively studied in the
circuit of fear, where GABA interneurons play key parts in the acquisition, storage and …

Brain function is based on an exquisite balance between excitatory and inhibitory
neurotransmission. GABAergic neurons provide the major inhibitory control. By controlling …

Publisher Summary This chapter demonstrates that molecular biology of GABA A receptors
in the central nervous system (CNS) has demonstrated remarkable heterogeneity in the …

This review assesses the parallel data on the role of gamma‐aminobutyric acid (GABA) in
depression and anxiety. We review historical and new data from both animal and human …

Since the pioneering discovery of the rapid CNS depressant actions of steroids by the “father
of stress,” Hans Seyle 70 years ago, brain-derived “neurosteroids” have emerged as …

Depression and anxiety are psychiatric disorders with high morbidity and comorbidity.
Because of multiple adverse effects of existing drugs and a low efficacy, therapy for a …

Dysfunction of the gamma amino butyric acid (GABA)-ergic system has been purported to
play a role in psychiatric disorders, including anxiety and major depression. A clear link …