Tiling array and novel sequencing technologies have made available the transcription
profile of the entire human genome. However, the extent of transcription and the function of …

With rapid development of sequencing technologies such as deep sequencing and whole
genome high-density tiling array, we now know that most of the “junk” genomic sequences …

The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding
of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at …

Recent advances in tiling array and high throughput analyses revealed that at least 87.3% of
the human genome is actively transcribed, though< 3% of the human genome encodes …

Long noncoding RNAs (lncRNAs) have been detected in nearly every cell type and found to
be fundamentally involved in many biological processes. The characterization of lncRNAs …

Once thought to be a part of the 'dark matter'of the genome, long non-coding RNAs
(lncRNAs) are emerging as an integral functional component of the mammalian …

While our understanding of the molecular mechanisms underlying cancer has significantly
improved, most of our knowledge focuses on protein-coding genes that make up a fraction of …

The conventional view of gene regulation in biology has centered around protein-coding
genes via the central dogma of DNA→ mRNA→ protein. The discovery of thousands of long …

Long noncoding RNAs (lncRNAs) have recently gained considerable attention as key
players in biological regulation; however, the mechanisms by which lncRNAs govern …

Recent advances in genome and transcriptome analysis have enabled identification of
numerous members of a new class of noncoding RNA, long noncoding RNA (lncRNA) …