Targeting Key Players of Neuroendocrine Differentiation in Prostate Cancer

I Zamora, MR Freeman, IJ Encío, M Rotinen - International Journal of …, 2023 - mdpi.com
Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer
(PC) that commonly emerges through a transdifferentiation process from prostate …

Molecular mechanisms of neuroendocrine differentiation in prostate cancer progression

Y Xie, S Ning, J Hu - Journal of Cancer Research and Clinical Oncology, 2022 - Springer
Background Rapid evolution of the therapeutic management of prostate cancer, especially
in in second-generation androgen inhibitors, has increased the opportunity of transformation …

Molecular events in neuroendocrine prostate cancer development

Y Wang, Y Wang, X Ci, SYC Choi, F Crea, D Lin… - Nature Reviews …, 2021 - nature.com
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. NEPC arises
de novo only rarely; the disease predominantly develops from adenocarcinoma in response …

Neuroendocrine differentiation of prostate cancer—An intriguing example of tumor evolution at play

GK Patel, N Chugh, M Tripathi - Cancers, 2019 - mdpi.com
Our understanding of neuroendocrine prostate cancer (NEPC) has assumed a new
perspective in light of the recent advances in research. Although classical NEPC is rarely …

The many faces of neuroendocrine differentiation in prostate cancer progression

S Terry, H Beltran - Frontiers in oncology, 2014 - frontiersin.org
In normal prostate, neuroendocrine (NE) cells are rare and interspersed among the
epithelium. These cells are believed to provide trophic signals to epithelial cell populations …

Understanding the molecular regulators of neuroendocrine prostate cancer.

S Bhattacharya, A Stillahn, K Smith… - Advances in Cancer …, 2024 - europepmc.org
Worldwide, prostate cancer (PCa) remains a leading cause of death in men. Histologically,
the majority of PCa cases are classified as adenocarcinomas, which are mainly composed …

Neuroendocrine differentiation in prostate cancer: novel morphological insights and future therapeutic perspectives

M Santoni, A Conti, L Burattini, R Berardi… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Neuroendocrine prostate cancer (NEPC) is an aggressive variant of prostate cancer that
commonly arises in later stages of castration resistant prostate cancer (CRPC) The detection …

Clinical and biological features of neuroendocrine prostate cancer

Y Yamada, H Beltran - Current oncology reports, 2021 - Springer
Abstract Purpose of Review Neuroendocrine prostate cancer (NEPC) is an aggressive
histologic subtype of prostate cancer that most commonly arises in later stages of prostate …

Molecular mechanisms underlying the development of neuroendocrine prostate cancer

S Liu, BR Alabi, Q Yin, T Stoyanova - Seminars in Cancer Biology, 2022 - Elsevier
Prostate cancer is the most common non-cutaneous cancer and the second leading cause
of cancer-associated deaths among men in the United States. Androgen deprivation therapy …

[HTML][HTML] Advances in neuroendocrine prostate cancer research: From model construction to molecular network analyses

X Shui, R Xu, C Zhang, H Meng, J Zhao, C Shi - Laboratory investigation, 2022 - Elsevier
Prostate cancer is the most common cancer among men and has a high incidence and
associated mortality worldwide. It is an androgen-driven disease in which tumor growth is …