Mendel's laws, Mendelian randomization and causal inference in observational data: substantive and nomenclatural issues
We respond to criticisms of Mendelian randomization (MR) by Mukamal, Stampfer and Rimm
(MSR). MSR consider that MR is receiving too much attention and should be renamed. We …
(MSR). MSR consider that MR is receiving too much attention and should be renamed. We …
Mendelian randomisation and causal inference in observational epidemiology
Mendelian Randomisation and Causal Inference in Observational Epidemiology | PLOS
Medicine Skip to main content Advertisement PLOS Medicine Browse Current Issue Journal …
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Nature as a trialist?: deconstructing the analogy between Mendelian randomization and randomized trials
Mendelian randomization (MR) studies are often described as naturally occurring
randomized trials in which genetic factors are randomly assigned by nature …
randomized trials in which genetic factors are randomly assigned by nature …
Credible Mendelian randomization studies: approaches for evaluating the instrumental variable assumptions
MM Glymour, EJ Tchetgen Tchetgen… - American journal of …, 2012 - academic.oup.com
As with other instrumental variable (IV) analyses, Mendelian randomization (MR) studies
rest on strong assumptions. These assumptions are not routinely systematically evaluated in …
rest on strong assumptions. These assumptions are not routinely systematically evaluated in …
Ten simple rules for conducting a mendelian randomization study
SA Gagliano Taliun, DM Evans - PLoS computational biology, 2021 - journals.plos.org
Mendelian randomization (MR) is an epidemiological technique for estimating causal
relationships using observational data, which has become very popular in recent years …
relationships using observational data, which has become very popular in recent years …
Methodological challenges in mendelian randomization
We give critical attention to the assumptions underlying Mendelian randomization analysis
and their biological plausibility. Several scenarios violating the Mendelian randomization …
and their biological plausibility. Several scenarios violating the Mendelian randomization …
Using Mendelian randomisation to assess causality in observational studies
Objective Mendelian randomisation (MR) is a technique that aims to assess causal effects of
exposures on disease outcomes. The paper aims to present the main assumptions that …
exposures on disease outcomes. The paper aims to present the main assumptions that …
Recent developments in Mendelian randomization studies
Abstract Purpose of Review Mendelian randomization (MR) is a strategy for evaluating
causality in observational epidemiological studies. MR exploits the fact that genotypes are …
causality in observational epidemiological studies. MR exploits the fact that genotypes are …
Interpreting findings from Mendelian randomization using the MR-Egger method
S Burgess, SG Thompson - European journal of epidemiology, 2017 - Springer
Abstract Mendelian randomization-Egger (MR-Egger) is an analysis method for Mendelian
randomization using summarized genetic data. MR-Egger consists of three parts:(1) a test …
randomization using summarized genetic data. MR-Egger consists of three parts:(1) a test …
An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings
E Sanderson, G Davey Smith… - International journal …, 2019 - academic.oup.com
Background Mendelian randomization (MR) is a powerful tool in epidemiology that can be
used to estimate the causal effect of an exposure on an outcome in the presence of …
used to estimate the causal effect of an exposure on an outcome in the presence of …