An efficient discovery strategy by combining diversity-oriented synthesis and converging
cellular screening is described. By a three-round screening process, we identified novel …

Nature makes many pharmacologically active compounds containing thiazolidine and
thiazolidinone scaffolds. These privileged structures have been identified in many random …

Privileged structures like Benzothiazole and Pyrrolobenzodiazepine offer wonderful
opportunity to explore in anti-cancer drug discovery as a mean to counter drug-resistance …

This study has achieved the design and diversity-oriented synthesis of novel 1, 4-thiazepine
derivatives embedded with carbazole, pyrazole or isoxazole motif via microwave-assisted …

Abstract Development of drugs for new and persistent diseases will increasingly rely on the
expansion of accessible chemical space to allow exploration of novel molecular targets …

Cancer continues to be one of the biggest threats to the human civilization because there is
no cure of it. Small heterocyclic molecule with low molecular weight and novel structural …

Curcumin is a natural product displaying a broad range of biological activities, including
anticancer properties. It is, however, poorly absorbed by the human body and, as a so-called …

Combinatorial library based on a biologically relevant core template, 2-aminothiazole, with
immense scope of diversity multiplication was designed for anticancer therapeutics. The …

[1, 5] Benzothiazepines are widely used in a number of different therapeutic areas and
therefore represent an interesting scaffold for de novo exploration. Recent literature reports …

In this strategy, we attempt to design various novel nitrogen-rich heterocycles in one
molecule. Green, simple, and efficient aza-annulations of an active, versatile building block …