Multiple sclerosis (MS) is characterized by heterogeneity in disease course and prediction of
long-term outcome remains a major challenge. Here, we investigate five myeloid markers …

Objective Evidence for a role of microglia in the pathogenesis of multiple sclerosis (MS) is
growing. We investigated association of microglial markers at time of diagnostic lumbar …

Objectives Neurochemical markers of amyotrophic lateral sclerosis (ALS) that reflect
underlying disease mechanisms might help in diagnosis, staging and prediction of outcome …

Neuroinflammation significantly contributes to Amyotrophic Lateral Sclerosis (ALS)
pathology. In lieu of this, reports of elevated chitinase levels in ALS are interesting, as they …

In demyelinating diseases including multiple sclerosis (MS), neural stem cells (NSCs) can
replace damaged oligodendrocytes if the local microenvironment supports the required …

Elevated levels of Chitinase-3-like protein-1 (CHI3L1) in cerebrospinal fluid have previously
been linked to inflammatory activity and disease progression in multiple sclerosis (MS) …

Abstract Chitinase 3-like 1 (CHI3L1) has been proposed as a biomarker associated with the
conversion to clinically definite multiple sclerosis in patients with clinically isolated …

Activated macrophages are major effectors at all stages of lesion formation in multiple
sclerosis (MS) brain. Here, we report that the macrophage enzyme chitotriosidase (Chit) is …

Background and purpose The role of chitinases and chitinase‐like proteins in multiple
sclerosis (MS) is currently unknown; however, cerebrospinal fluid (CSF) levels of chitinase 3 …

Neurological disorders are highly prevalent and often lead to chronic debilitating disease.
Neuroinflammation is a major driver across the spectrum of disorders, and microglia are key …