Physical stability of amorphous solid dispersions: a physicochemical perspective with thermodynamic, kinetic and environmental aspects

X Lin, Y Hu, L Liu, L Su, N Li, J Yu, B Tang… - Pharmaceutical …, 2018 - Springer
Abstract Purpose Amorphous solid dispersions (ASDs) have been widely used in the
pharmaceutical industry for solubility enhancementof poorly water-soluble drugs. The …

[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

SV Bhujbal, B Mitra, U Jain, Y Gong, A Agrawal… - … Pharmaceutica Sinica B, 2021 - Elsevier
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

[HTML][HTML] Thermal stability of amorphous solid dispersions

D Jelić - Molecules, 2021 - mdpi.com
Amorphous solid dispersion drug delivery systems (ASD DDS) were proved to be efficient
for the enhancement of solubility and bioavailability of poorly water-soluble drugs. One of …

[HTML][HTML] Solvent influence on the phase behavior and glass transition of Amorphous Solid Dispersions

S Dohrn, C Luebbert, K Lehmkemper… - European Journal of …, 2021 - Elsevier
Understanding the long-term stability of amorphous solid dispersions (ASDs) is important for
their successful approval for market. ASD stability does not only depend on the interplay …

Characterization of amorphous solid dispersions: An update

X Ma, RO Williams III - Journal of Drug Delivery Science and Technology, 2019 - Elsevier
Amorphous solid dispersions (ASDs) are a promising formulation approach to improve the
solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have …

Effects of the preparation process on the properties of amorphous solid dispersions

S Huang, RO Williams - Aaps Pharmscitech, 2018 - Springer
The use of amorphous solid dispersions to improve the bioavailability of active ingredients
from the BCS II and IV classifications continues to gain interest in the pharmaceutical …

Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products

P Pandi, R Bulusu, N Kommineni, W Khan… - International journal of …, 2020 - Elsevier
Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …

New strategies for improving the development and performance of amorphous solid dispersions

A Haser, F Zhang - Aaps Pharmscitech, 2018 - Springer
The understanding of amorphous solid dispersions has grown significantly in the past
decade. This is evident from the number of approved commercial amorphous solid …

Excipients for amorphous solid dispersions

SRK Vaka, MM Bommana, D Desai, J Djordjevic… - … dispersions: Theory and …, 2014 - Springer
Pharmaceutical excipients play a significant role in stabilization of amorphous solid
dispersions, as these systems are thermodynamically unstable. This chapter illustrates the …

Physical stability of amorphous pharmaceutical solids: Nucleation, crystal growth, phase separation and effects of the polymers

Q Shi, F Li, S Yeh, Y Wang, J Xin - International journal of pharmaceutics, 2020 - Elsevier
Compared to their crystalline forms, amorphous pharmaceutical solids present marvelous
potential and advantages for effectively improving the oral bioavailability of poorly water …