Lysosomal storage disorders (LSDs) are a vast group of more than 50 clinically identified
metabolic diseases. They are singly rare, but they affect collectively 1 on 5,000 live births …

Lysosomal storage diseases (LSDs) comprise a group of rare inherited chronic syndromes
that cause deficiency of specific native enzymes within the lysosomes. The macromolecular …

Lysosomal storage diseases (LSDs) are a group of rare genetic multisystemic disorders,
resulting in deficient lysosomal activity. These pathologies are characterized by progressive …

Lysosomal storage diseases (LSDs) are a heterogeneous group of genetic disorders
caused by defects in lysosomal function that lead to multiorgan system damage. Due to wide …

Genetic mutations that cause specific lysosomal protein deficiencies account for more than
45 Lysosomal Storage Diseases (LSDs), mostly pre-adult disorders which are associated …

Lysosomes and lysosomal enzymes play a central role in numerous cellular processes,
including cellular nutrition, recycling, signaling, defense, and cell death. Genetic deficiencies …

Abstract Approximately 1 in 5000–8000 children are born annually with a lysosomal storage
disease (LSD), which affects their cells' ability to break down naturally occurring substrates …

Despite many beneficial outcomes of the conventional enzyme replacement therapy (ERT),
several limitations such as the high-cost of the treatment and various inadvertent side effects …

Background: The therapy of the lysosomal storage diseases (LSDs) was developed by
supplying adequate amounts of the needed enzyme to affected individuals. This approach in …

Introduction: Lysosomal storage disorders (LSDs) are clinically heterogeneous disorders
that result primarily from lysosomal accumulation of macromolecules in various tissues …