Mammals survive starvation by activating proteolysis and lipolysis in many different tissues.
These responses are triggered, at least in part, by changing hormonal and neural statuses …

Muscular and hepatic abnormalities observed in artificially fed critically ill patients strikingly
resemble the phenotype of autophagy-deficient mice. Autophagy is the only pathway to clear …

The liver is critical for maintaining systemic energy balance during starvation. To understand
the role of hepatic fatty acid β-oxidation on this process, we generated mice with a liver …

Chaperone-mediated autophagy (CMA) is a selective lysosomal proteindegradative process
that is activated in higher organisms under conditions ofprolonged starvation and in cell …

Macroautophagy (henceforth referred to as autophagy) is an in-bulk lysosomal degradative
pathway that plays a crucial role in the maintenance of cellular homeostasis through the …

The ubiquitin-proteasome proteolytic system is stimulated in conditions causing muscle
atrophy. Signals initiating this response in these conditions are unknown, although …

All intracellular proteins and many extracellular proteins are continually “turning over”; ie,
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis …

A high-fat diet is one of the causative factors of obesity. The dietary profile of fatty acids is
also an important variable in developing obesity, as saturated fatty acids are more …

Autophagy mediates the degradation of cellular components in lysosomes, assuring
removal of altered or dysfunctional proteins and organelles. Autophagy is not only activated …

Starvation is a strong physiological stimulus of macroautophagy/autophagy. In this study, we
addressed the question as to whether it would be possible to measure autophagy in blood …