Oral subacute exposure to cadmium LOAEL dose induces insulin resistance and impairment of the hormonal and metabolic liver-adipose axis in Wistar rats

VE Sarmiento-Ortega, D Moroni-González… - Biological trace element …, 2022 - Springer
Cadmium is a nonessential transition metal considered one of the more hazardous
environmental contaminants. The population is chronically exposed to this metal at low …

Chronic cadmium exposure in rats produces pancreatic impairment and insulin resistance in multiple peripheral tissues

S Treviño, MP Waalkes, JAF Hernández… - Archives of biochemistry …, 2015 - Elsevier
Previous studies have linked cadmium exposure to disturbances in carbohydrate and lipid
metabolism. In this study we investigate the effects in Wistar rats of an oral cadmium …

ROS and ERK pathway mechanistic approach on hepatic insulin resistance after chronic oral exposure to cadmium NOAEL dose

VE Sarmiento-Ortega, D Moroni-González… - … Trace Element Research, 2023 - Springer
Cadmium is a critical toxic agent in occupational and non-occupational settings and acute
and chronic environmental exposure situations that have recently been associated with …

[HTML][HTML] Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes

M Gasser, S Lenglet, N Bararpour, T Sajic, K Wiskott… - Toxicology, 2022 - Elsevier
Obesity is considered as a major public health concern with strong economic and social
burdens. Exposure to pollutants such as heavy metals can contribute to the development of …

Decreased insulin secretion but unchanged glucose homeostasis in cadmium‐exposed male C57BL/6 mice

X Li, M Li, J Xu, X Zhang, W Xiao… - Journal of …, 2019 - Wiley Online Library
Cadmium (Cd) is a well‐known toxic metal element that is largely distributed in the
environment. Cd causes toxicity to most organs. Accumulating evidence suggests that Cd …

Changes on serum and hepatic lipidome after a chronic cadmium exposure in Wistar rats

VE Sarmiento-Ortega, S Treviño… - Archives of biochemistry …, 2017 - Elsevier
Cadmium (Cd) is a transition metal, which is considered one of the top five more hazardous
environmental contaminants by the Agency for Toxic Substances and Disease Registry [1] …

Cadmium exposure decreases fasting blood glucose levels and exacerbates type-2 diabetes in a mouse model

M Li, S Wang, X Liu, Z Sheng, B Li, J Li, J Zhang… - Endocrine, 2022 - Springer
Purpose Although the effects of cadmium (Cd) on the development of diabetes have been
extensively investigated, the relationship between Cd exposure and the severity of …

The NOAEL Metformin dose is ineffective against metabolic disruption induced by chronic cadmium exposure in Wistar rats

VE Sarmiento-Ortega, E Brambila… - Toxics, 2018 - mdpi.com
Previous studies have proposed that cadmium (Cd) is a metabolic disruptor, which is
associated with insulin resistance, metabolic syndrome, and diabetes. This metal is not …

Pancreas–liver–adipose axis: target of environmental cadmium exposure linked to metabolic diseases

D Moroni-González, VE Sarmiento-Ortega, A Diaz… - Toxics, 2023 - mdpi.com
Cadmium has been well recognized as a critical toxic agent in acute and chronic poisoning
cases in occupational and nonoccupational settings and environmental exposure situations …

Long lasting cadmium intake is associated with reduction of insulin receptors in rat adipocytes

M Ficková, V Eybl, D Kotyzová, V Mičková, S Möstbök… - Biometals, 2003 - Springer
The effects of chronic cadmium exposure on adipose tissue have not been extensively
reported. In adult Wistar male rats we investigated in vivo effect of 6 weeks lasting cadmium …