Background The effects of diabetes on the cardiac and aortic structure and function remain
unclear. Detecting and intervening these variations early is crucial for the prevention and …

Aims Type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular disease
(CVD) risk, but whether T2DM directly causes adverse cardiac remodelling is uncertain. We …

Background Mortality attributable to heart failure remains high. The prevalence of heart
failure in patients with diabetes mellitus ranges from 19 to 26%. It is estimated that up to 21.1 …

Background Adverse ventricular structure and function is a key pathogenic mechanism of
heart failure. Observational studies have shown that both insulin resistance (IR) and …

Background Human physiology and disease are defined by complex interactions between
genetic and environmental factors. While genome-wide association studies (GWASs) have …

Background: Diabetes mellitus (DM) is associated with increased risk of cardiovascular
disease. Detection of early cardiac changes before manifest disease develops is important …

Background The success of translational research depends on how well animal models
mimic the pathophysiology of the human phenotype, and on the identification of disease …

Background Both non-alcoholic fatty liver disease (NAFLD) and Type 2 diabetes increase
the risk of developing cardiovascular disease. The metabolic processes underlying NAFLD …

Objectives. In a cohort of type 2 diabetic (T2D) patients who underwent baseline cardiac
magnetic resonance (CMR) and biomarker testing, during a median follow‐up of 6 years, we …

Background: The genetic basis of left ventricular (LV) image-derived phenotypes, which play
a vital role in the diagnosis, management, and risk stratification of cardiovascular diseases …