Physiological significance of α2-adrenergic receptor subtype diversity: one receptor is not enough

M Philipp, M Brede, L Hein - American Journal of …, 2002 - journals.physiology.org
α2-Adrenergic receptors mediate part of the diverse biological effects of the endogenous
catecholamines epinephrine and norepinephrine. Three distinct subtypes of α2-adrenergic …

α1-Adrenergic receptors: new insights and directions

MT Piascik, DM Perez - Journal of Pharmacology and Experimental …, 2001 - ASPET
The adrenergic receptors play a key role in the modulation of sympathetic nervous system
activity as well as a site of action for many therapeutic agents. The α1-adrenergic receptor …

In vivo gene modification elucidates subtype-specific functions of α2-adrenergic receptors

JW Kable, LC Murrin, DB Bylund - Journal of Pharmacology and …, 2000 - ASPET
Mice with altered α2-adrenergic receptor genes have become important tools in elucidating
the subtype-specific functions of the three α2-adrenergic receptor subtypes because of the …

The α1-adrenergic receptors: diversity of signaling networks and regulation

S Cotecchia - Journal of Receptors and Signal Transduction, 2010 - Taylor & Francis
The α1-adrenergic receptor (AR) subtypes (α1a, α1b, and α1d) mediate several
physiological effects of epinephrine and norepinephrine. Despite several studies in …

α2-Adrenoceptor subtypes—Unexpected functions for receptors and ligands derived from gene-targeted mouse models

AE Knaus, V Muthig, S Schickinger, E Moura… - Neurochemistry …, 2007 - Elsevier
α2-Adrenoceptors belong to the group of nine adrenoceptors which mediate the biological
actions of the endogenous catecholamines adrenaline and noradrenaline. Studies with …

Genetic dissection of α2-adrenoceptor functions in adrenergic versus nonadrenergic cells

R Gilsbach, C Röser, N Beetz, M Brede… - Molecular …, 2009 - ASPET
α2-Adrenoceptors mediate diverse functions of the sympathetic system and are targets for
the treatment of cardiovascular disease, depression, pain, glaucoma, and sympathetic …

α2‐Adrenergic Receptor Subtypes — Novel Functions Uncovered in Gene‐Targeted Mouse Models

M Brede, M Philipp, A Knaus, V Muthig… - Biology of the …, 2004 - Wiley Online Library
Summry—The family of adrenergic receptors contains nine different subtypes of G protein‐
coupled receptors which mediate the biological effects of adrenaline and noradrenaline …

Are the pharmacology and physiology of α2adrenoceptors determined by α2‐heteroreceptors and autoreceptors respectively?

R Gilsbach, L Hein - British journal of pharmacology, 2012 - Wiley Online Library
α2‐Adrenoceptors are important mediators of physiological responses to the endogenous
catecholamines noradrenaline and adrenaline. In addition, α2‐adrenoceptors are …

[HTML][HTML] Identification of Critical Determinants of α1-Adrenergic Receptor Subtype Selective Agonist Binding (∗)

J Hwa, RM Graham, DM Perez - Journal of Biological Chemistry, 1995 - ASBMB
α 1-Adrenergic receptor (AR) subtypes mediate many effects of the sympathetic nervous
system. The three cloned subtypes (α 1a-AR, α 1b-AR, α 1d-AR), although structurally …

Abnormal regulation of the sympathetic nervous system in α2A-adrenergic receptor knockout mice

JD Altman, AU Trendelenburg, L MacMillan… - Molecular …, 1999 - ASPET
α2-Adrenergic receptors (ARs) play a key role in regulating neurotransmitter release in the
central and peripheral sympathetic nervous systems. To date, three subtypes of α2-ARs …