Gap junctions are membrane structures made of intercellular channels which permit the
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …

Gap junctions are intercellular plasma membrane domains enriched in channels that allow
direct exchange of ions and small molecules between adjacent cells. Gap junction channels …

Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …

The hypothesis, that gap junctional intercellular communication plays a key role in
carcinogenesis and more generally in growth control was formulated nearly 40 years ago …

Formation of metastases negatively impacts the survival prognosis of cancer patients.
Globally, if the various steps involved in their formation are relatively well identified, the …

Tumour development is a process resulting from the disturbance of various cellular functions
including cell proliferation, adhesion and motility. While the role of these cell parameters in …

Direct communication between cells, mediated by gap junctions, is nowadays considered as
an indispensable mechanism in the maintenance of cellular homeostasis. In fact, gap …

Gap junctions are comprised of proteinaceous, plasma membrane channels that link the
interiors of adjacent cells and permit cells to directly exchange small (< 1,000 Daltons) …

Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …

There is a large body of evidence suggesting the connexin gap junction proteins appear to
act as tumor suppressors, and their tumor inhibitory effect is usually attributed to their main …