Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer

F Rödel, J Hoffmann, L Distel, M Herrmann… - Cancer research, 2005 - AACR
Apoptosis levels have been shown to predict tumor response to preoperative
radiochemotherapy in rectal cancer. Recently, the prominent role of survivin, a structurally …

Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: survivin as a radioresistance factor

C Rödel, J Haas, A Groth, GG Grabenbauer… - International Journal of …, 2003 - Elsevier
BACKGROUND: Spontaneous apoptosis has been shown to predict tumor response to
radiochemotherapy in rectal cancer in vivo. It remains to be elucidated, however, which …

Survivin expression is an independent prognostic factor in rectal cancer patients with and without preoperative radiotherapy

A Knutsen, G Adell, XF Sun - International Journal of Radiation Oncology …, 2004 - Elsevier
PURPOSE: Survivin, as an inhibitor of apoptosis, is undetectable in normal tissues but
expressed in tumors. Survivin expression in rectal cancer patients who have undergone …

Radiation-induced survivin nuclear accumulation is linked to DNA damage repair

G Capalbo, K Dittmann, C Weiss, S Reichert… - International Journal of …, 2010 - Elsevier
PURPOSE: Increased expression of survivin has been identified as a negative prognostic
marker in a variety of human cancers. We have previously shown that survivin is a radiation …

Survivin antisense oligonucleotides effectively radiosensitize colorectal cancer cells in both tissue culture and murine xenograft models

F Rödel, B Frey, W Leitmann, G Capalbo… - International Journal of …, 2008 - Elsevier
PURPOSE: Survivin shows a radiation resistance factor in colorectal cancer. In the present
study, we determined whether survivin messenger RNA levels in patients with rectal cancer …

[PDF][PDF] The role of survivin for radiation therapy

G Capalbo, RH Stauber, SK Knauer… - Strahlentherapie und …, 2007 - academia.edu
Background: Survivin, the smallest member of the inhibitor of apoptosis protein (IAP) family,
is a bifunctional protein that has been implicated in both control of cell division and inhibition …

Radiosensitization, after a combined treatment of survivin siRNA and irradiation, is correlated with the activation of caspases 3 and 7 in a wt-p53 sarcoma cell line, but …

M Kappler, H Taubert, F Bartel… - Oncology …, 2005 - spandidos-publications.com
Survivin, a member of the inhibitor-of-apoptosis family is an essential protein for regular
mitosis and is involved in an anti-apoptotic pathway. In some studies, an association …

Down-regulation of survivin by oxaliplatin diminishes radioresistance of head and neck squamous carcinoma cells

Z Khan, N Khan, RP Tiwari, IK Patro, G Prasad… - Radiotherapy and …, 2010 - Elsevier
BACKGROUND: Oxaliplatin is integrated in treatment strategies against a variety of cancers
including radiation protocols. Herein, as a new strategy we tested feasibility and rationale of …

Survivin as a radioresistance factor in pancreatic cancer

K Asanuma, R Moriai, T Yajima… - Japanese journal of …, 2000 - Wiley Online Library
We examined whether survivin acts as a constitutive and inducible radioresistance factor in
pancreatic cancer cells. Using a quantitative TaqMan reverse transcription‐polymerase …

Downregulation of survivin by siRNA diminishes radioresistance of pancreatic cancer cells

K Kami, R Doi, M Koizumi, E Toyoda, T Mori, D Ito… - Surgery, 2005 - Elsevier
BACKGROUND: Survivin is a member of the inhibitor of apoptosis protein family, which
inhibits apoptosis and regulates cell division. Survivin is expressed by the majority of human …