Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer
Apoptosis levels have been shown to predict tumor response to preoperative
radiochemotherapy in rectal cancer. Recently, the prominent role of survivin, a structurally …
radiochemotherapy in rectal cancer. Recently, the prominent role of survivin, a structurally …
Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: survivin as a radioresistance factor
C Rödel, J Haas, A Groth, GG Grabenbauer… - International Journal of …, 2003 - Elsevier
BACKGROUND: Spontaneous apoptosis has been shown to predict tumor response to
radiochemotherapy in rectal cancer in vivo. It remains to be elucidated, however, which …
radiochemotherapy in rectal cancer in vivo. It remains to be elucidated, however, which …
Survivin expression is an independent prognostic factor in rectal cancer patients with and without preoperative radiotherapy
A Knutsen, G Adell, XF Sun - International Journal of Radiation Oncology …, 2004 - Elsevier
PURPOSE: Survivin, as an inhibitor of apoptosis, is undetectable in normal tissues but
expressed in tumors. Survivin expression in rectal cancer patients who have undergone …
expressed in tumors. Survivin expression in rectal cancer patients who have undergone …
Radiation-induced survivin nuclear accumulation is linked to DNA damage repair
G Capalbo, K Dittmann, C Weiss, S Reichert… - International Journal of …, 2010 - Elsevier
PURPOSE: Increased expression of survivin has been identified as a negative prognostic
marker in a variety of human cancers. We have previously shown that survivin is a radiation …
marker in a variety of human cancers. We have previously shown that survivin is a radiation …
Survivin antisense oligonucleotides effectively radiosensitize colorectal cancer cells in both tissue culture and murine xenograft models
PURPOSE: Survivin shows a radiation resistance factor in colorectal cancer. In the present
study, we determined whether survivin messenger RNA levels in patients with rectal cancer …
study, we determined whether survivin messenger RNA levels in patients with rectal cancer …
[PDF][PDF] The role of survivin for radiation therapy
G Capalbo, RH Stauber, SK Knauer… - Strahlentherapie und …, 2007 - academia.edu
Background: Survivin, the smallest member of the inhibitor of apoptosis protein (IAP) family,
is a bifunctional protein that has been implicated in both control of cell division and inhibition …
is a bifunctional protein that has been implicated in both control of cell division and inhibition …
Radiosensitization, after a combined treatment of survivin siRNA and irradiation, is correlated with the activation of caspases 3 and 7 in a wt-p53 sarcoma cell line, but …
M Kappler, H Taubert, F Bartel… - Oncology …, 2005 - spandidos-publications.com
Survivin, a member of the inhibitor-of-apoptosis family is an essential protein for regular
mitosis and is involved in an anti-apoptotic pathway. In some studies, an association …
mitosis and is involved in an anti-apoptotic pathway. In some studies, an association …
Down-regulation of survivin by oxaliplatin diminishes radioresistance of head and neck squamous carcinoma cells
BACKGROUND: Oxaliplatin is integrated in treatment strategies against a variety of cancers
including radiation protocols. Herein, as a new strategy we tested feasibility and rationale of …
including radiation protocols. Herein, as a new strategy we tested feasibility and rationale of …
Survivin as a radioresistance factor in pancreatic cancer
K Asanuma, R Moriai, T Yajima… - Japanese journal of …, 2000 - Wiley Online Library
We examined whether survivin acts as a constitutive and inducible radioresistance factor in
pancreatic cancer cells. Using a quantitative TaqMan reverse transcription‐polymerase …
pancreatic cancer cells. Using a quantitative TaqMan reverse transcription‐polymerase …
Downregulation of survivin by siRNA diminishes radioresistance of pancreatic cancer cells
K Kami, R Doi, M Koizumi, E Toyoda, T Mori, D Ito… - Surgery, 2005 - Elsevier
BACKGROUND: Survivin is a member of the inhibitor of apoptosis protein family, which
inhibits apoptosis and regulates cell division. Survivin is expressed by the majority of human …
inhibits apoptosis and regulates cell division. Survivin is expressed by the majority of human …
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