The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

Mutations in nuclear lamins or other proteins of the nuclear envelope are the root cause of a
group of phenotypically diverse genetic disorders known as laminopathies, which have …

In recent years, our perspective on the cell nucleus has evolved from the view that it is a
passive but permeable storage organelle housing the cell's genetic material to an …

The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. In recent years, mutations in nuclear‐envelope proteins have been shown …

Most inherited diseases are associated with mutations in a specific gene. Sometimes,
mutations in two or more different genes result in diseases with a similar phenotype. Rarely …

Nuclear lamins form a fibrous nucleoskeletal network of intermediate‐sized filaments that
underlies the inner nuclear membrane. It associates with this membrane through …

Nuclear lamins are intermediate filament proteins that polymerize to form the nuclear lamina
on the inner aspect of the inner nuclear membrane. Long known to be essential for …

A group of human diseases, known as' laminopathies', are associated with defects in
proteins of the nuclear envelope. Most laminopathy mutations have been mapped to the A …

Most inherited diseases are associated with mutations in a specific gene. Often, mutations in
two or more different genes result in diseases with a similar phenotype. Rarely do different …

The main function of the nuclear lamina, an intermediate filament meshwork lying primarily
beneath the inner nuclear membrane, is to provide structural scaffolding for the cell nucleus …