In addition to their conventional role as a conduit system for gases, nutrients, waste products
or cells, blood vessels in the skeletal system play active roles in controlling multiple aspects …

Blood vessels are essential for the distribution of oxygen, nutrients, and immune cells, as
well as the removal of waste products. In addition to this conventional role as a versatile …

Recent advances in our understanding of blood vessels and vascular niches in bone convey
their critical importance in regulating bone development and physiology. The contribution of …

In addition to their conventional role as a versatile transport system, blood vessels provide
signals controlling organ development, regeneration, and stem cell behavior. In the skeletal …

Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete
angiocrine factors required for the survival, maintenance, and self‐renewal of stem and …

Bone provides nurturing microenvironments for an array of cell types that coordinate
important physiological functions of the skeleton, such as energy metabolism, mineral …

During bone development, homeostasis and repair, a dense vascular system provides
oxygen and nutrients to highly anabolic skeletal cells. Characteristic for the vascular system …

Adequate vascularization is an absolute requirement for bone development, growth,
homeostasis, and repair. Endochondral ossification during fetal skeletogenesis is typified by …

Blood vessels form a versatile transport network that is best known for its critical roles in
processes such as tissue oxygenation, metabolism and immune surveillance. The …

Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New
blood vessel formation is crucial during both primary bone development as well as fracture …