Pharmacokinetic data in obesity are only available for a limited number of drugs. The rate or
extent of drug absorption is not known to be altered by obesity which is not complicated by …

Drug disposition for many drugs has now been studied in obese individuals and some
general conclusions can be drawn. Absorption of drugs evaluated to date is unchanged due …

In the obese, modifications in body constitution (higher percentage of fat and lower
percentage of lean tissue and water) can affect drug distribution in the tissues. For slightly …

Physiologic changes associated with obesity and their effects on the distribution, protein
binding, metabolism, and renal excretion of drugs are described. Changes in the volume of …

Obesity is common enough to constitute a serious medical and public health problem. Drug
prescription for obese patients is difficult since dosages based on pharmacokinetic data …

Obesity is a worldwide problem, with major health, social and economic implications. The
adaptation of drug dosages to obese patients is a subject of concern, particularly for drugs …

Abstract In 1979, the late Dr. Darrell R. Abernethy and colleagues began a series of clinical
studies aimed at understanding the pertinent determinants of drug distribution, elimination …

The prevalence of obesity has dramatically increased in recent years and now includes a
significant proportion of the world's children, adolescents and adults. Obesity is linked to a …

Obesity is a disease characterized as a condition resulting from the excess accumulation of
body fat. In conjunction with increased stores of body fat, obesity has also been associated …

Alterations in Drug Distribution and Clearance Due to Obesity1 Page 1 Vol. 217. No.3
PinSed in USA 681 0022-3565/81/21 73-06$I$02.OO/O THE JOURNAL OF …