The relationship between statin administration timing and survival outcomes in patients with cancer receiving immune checkpoint blockade

Z Wang, XY See, CH Chiang, YC Chang… - Journal of …, 2023 - Taylor & Francis
Objective Statins have been demonstrated to improve outcomes in patients receiving
immune checkpoint blockade (ICB). This study aimed to investigate whether the timing of …

The timing of statin initiation on survival outcomes of cancer patients treated with immune checkpoint inhibitors: A retrospective cohort study.

XY See, CH Chiang, CH Chiang, YJ Chen, YC Chang… - 2023 - ascopubs.org
e14672 Background: Concomitant use of statins has been associated with improved survival
outcomes in patients treated with immune checkpoint inhibitors (ICIs), but it is unclear if the …

Efficacy of lipophilic statins on outcomes of patients treated with immune checkpoint inhibitors

CH Chiang, YJ Chen, XY See, YC Chang, SS Wang… - Oncology, 2023 - karger.com
Background: Statins are associated with improved survival outcomes in patients receiving
immune checkpoint inhibitors (ICIs), but the impact of lipophilic and hydrophilic statin …

The effect of concomitant use of statins, NSAIDs, low-dose aspirin, metformin and beta-blockers on outcomes in patients receiving immune checkpoint inhibitors: a …

Y Zhang, H Chen, S Chen, Z Li, J Chen, W Li - Oncoimmunology, 2021 - Taylor & Francis
Immunotherapy shows promising therapeutic efficacy against various types of cancer, but
most fail to respond. Preclinical studies have suggested that concomitant medications, such …

[HTML][HTML] Statins and immune checkpoint inhibitors: a strategy to improve the efficacy of immunotherapy for cancer?

WG Vos, E Lutgens, TTP Seijkens - Journal for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
In the past decade, immune checkpoint inhibitor (ICI) therapy significantly improved the
prognosis of patients with cancer. Despite impressive and often unprecedented response …

Concomitant Statins and the Survival of Patients with Non‐Small‐Cell Lung Cancer Treated with Immune Checkpoint Inhibitors: A Meta‐Analysis

L Zhang, H Wang, J Tian, L Sui… - International Journal of …, 2022 - Wiley Online Library
Statins are suggested to improve cancer survival by possible anti‐inflammatory effect.
However, it remains unclear if concomitant use of statins could improve the efficacy of …

489 Statin drugs augment tumor response to anti-PD-1 immune check point blockade in head and neck cancer patients

TJ Kristoff, S Evans, P Nayi, M Abousaud, C Steuer… - 2023 - jitc.bmj.com
Background Anti-programmed cell death protein-1 (PD-1) immune checkpoint blockade
(ICB) has become a common first line treatment for head and neck squamous cell carcinoma …

Impact of early steroids use on clinical outcomes of patients with advanced NSCLC treated with immune checkpoint inhibitors

G Fucà, M Poggi, G Galli, M Imbimbo… - Annals of …, 2018 - annalsofoncology.org
Background: In advanced non-small cell lung cancer (NSCLC), immune checkpoint
inhibitors (ICIs) significantly improved patients (pts) prognosis, even if many factors could …

The prognostic role of high blood cholesterol in advanced cancer patients treated with immune checkpoint inhibitors

F Perrone, R Minari, M Bersanelli, P Bordi… - Journal of …, 2020 - journals.lww.com
Immune checkpoint inhibitors (ICI) have improved survival in numerous types of cancer.
However, a great number of unselected patients still do not respond to ICI. Moreover, there …

79P Statins and immunotherapy: Togetherness makes strength-the potential effect of statins on immunotherapy for NSCLC

M Filetti, A Rossi, M Piras, BT Salimbeni… - Annals of …, 2020 - annalsofoncology.org
Background Statins are commonly used agents in primary and secondary prevention of
cardiovascular disease, but recent studies suggested that they can display pleiotropic effects …