(−)-Cytisine (−)-1,[(1R, 5S)-1, 2, 3, 4, 5, 6-hexahydro-1, 5-methano-8H-pyrido [1, 2a][1, 5]
diazocin-8-one (Figure 1), is an alkaloid extracted from various plants belonging to the …

A Readily-Accessible (+)-Sparteine Surrogate | Journal of the American Chemical Society
ACS ACS Publications C&EN CAS Find my institution Log In Journal of the American …

Covering: up to the end of 2011 This review covers classical and modern structural
modifications of the alkaloid, the more recent (since 2007) syntheses of cytisine and …

Neuronal nicotinic acetylcholine receptors (nAChRs) form a family of ACh-gated cation
channels made up of different subtypes. They are widely distributed in peripheral and …

A series of pyridone ring-modified derivatives of (7R, 9S)-(−)-cytisine were evaluated for
affinity and functional activity at neuromuscular α1β1γδ, ganglionic α3β4, and central …

(–)-Sparteine, a naturally occurring lupin alkaloid, is widely used as a chiral ligand for
asymmetric synthesis. To address the limitation that sparteine is only available as its (–) …

Cytisine (cy) is a potent and competitive partial agonist at α4 subunit-containing nicotinic
acetylcholine (nACh) receptors while at homomeric α7-nACh receptors it behaves as a full …

Effects of cytisine (cy), 3‐bromocytisine (3‐Br‐cy), 5‐bromocytisine (5‐Br‐cy) and 3, 5‐
dibromocytisine (3, 5‐diBr‐cy) on human (h) α7‐, α4β2‐and α4β4 nicotinic acetylcholine …

Cytisine (−)‐Methyl (1R, 9R)‐6‐Oxo‐7, 11‐diazatricyclo [7.3. 1.02, 7] trideca‐2, 4‐diene‐11‐
carboxylic acid (+)‐(1R, 2S, 9S)‐11‐Methyl‐7, 11‐diazatricyclo [7.3. 1.02, 7] tridecane

We report the synthesis and pharmacological properties of several cytisine derivatives.
Among them, two 10-substituted derivatives showed much higher selectivities for the α4β2 …