Effectiveness of sofosbuvir, ledipasvir/sofosbuvir, or paritaprevir/ritonavir/ombitasvir and dasabuvir regimens for treatment of patients with hepatitis C in the Veterans …

GN Ioannou, LA Beste, MF Chang, PK Green, E Lowy… - Gastroenterology, 2016 - Elsevier
Background & Aims We investigated the real-world effectiveness of sofosbuvir,
ledipasvir/sofosbuvir, and paritaprevir/ritonavir/ombitasvir and dasabuvir (PrOD) in treatment …

Comparative effectiveness of ledipasvir/sofosbuvir±ribavirin vs. ombitasvir/paritaprevir/ritonavir+ dasabuvir±ribavirin in 6961 genotype 1 patients treated in routine …

LI Backus, PS Belperio, TA Shahoumian… - Alimentary …, 2016 - Wiley Online Library
Background Real‐world data are needed to inform hepatitis C virus (HCV) treatment
decisions. Aim To assess the comparative effectiveness of ledipasvir/sofosbuvir±ribavirin …

Effectiveness of ledipasvir-sofosbuvir combination in patients with hepatitis C virus infection and factors associated with sustained virologic response

NA Terrault, S Zeuzem, AM Di Bisceglie, JK Lim… - Gastroenterology, 2016 - Elsevier
Background & Aims The combination of ledipasvir and sofosbuvir has been approved for
treatment of genotype 1 hepatitis C virus (HCV) infection, including an 8-week regimen for …

Real‐world effectiveness of sofosbuvir/velpatasvir/voxilaprevir in 573 direct‐acting antiviral experienced hepatitis C patients

PS Belperio, TA Shahoumian, TP Loomis… - Journal of viral …, 2019 - Wiley Online Library
Abstract Sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) provides a needed hepatitis C
virus (HCV) antiviral option for direct‐acting antiviral (DAA)‐experienced patients. We …

Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus …

E Lawitz, FF Poordad, PS Pang, RH Hyland, X Ding… - The Lancet, 2014 - thelancet.com
Background Interferon-based treatment is not suitable for many patients with hepatitis C
virus (HCV) infection because of contraindications such as psychiatric illness, and a high …

Efficacy of ledipasvir and sofosbuvir, with or without ribavirin, for 12 weeks in patients with HCV genotype 3 or 6 infection

EJ Gane, RH Hyland, D An, E Svarovskaia, PS Pang… - Gastroenterology, 2015 - Elsevier
Background & Aims We performed a phase 2 clinical trial to evaluate the efficacy and safety
of ledipasvir and sofosbuvir, with or without ribavirin, in patients infected with hepatitis C …

Efficacy of nucleotide polymerase inhibitor sofosbuvir plus the NS5A inhibitor ledipasvir or the NS5B non-nucleoside inhibitor GS-9669 against HCV genotype 1 …

EJ Gane, CA Stedman, RH Hyland, X Ding… - Gastroenterology, 2014 - Elsevier
Background & Aims We evaluated an all-oral regimen comprising the nucleotide
polymerase inhibitor sofosbuvir (SOF) with the NS5A inhibitor ledipasvir (LDV) or the NS5B …

Ledipasvir‐sofosbuvir plus ribavirin for patients with genotype 1 hepatitis C virus previously treated in clinical trials of sofosbuvir regimens

D Wyles, P Pockros, G Morelli, Z Younes… - Hepatology, 2015 - journals.lww.com
Patients who fail to achieve sustained virological response (SVR) after treatment with
sofosbuvir (SOF) plus ribavirin (RBV) with or without pegylated interferon (Peg‐IFN) do not …

Effectiveness of sofosbuvir‐based regimens in genotype 1 and 2 hepatitis C virus infection in 4026 US Veterans

LI Backus, PS Belperio, TA Shahoumian… - Alimentary …, 2015 - Wiley Online Library
Background Real‐world effectiveness data are needed to inform hepatitis C virus (HCV)
treatment decisions. Aim To assess sustained virological response (SVR) of sofosbuvir …

Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection

N Afdhal, KR Reddy, DR Nelson, E Lawitz… - … England Journal of …, 2014 - Mass Medical Soc
Background Effective treatment for hepatitis C virus (HCV) genotype 1 infection in patients
who have not had a sustained virologic response to prior interferon-based therapy …